Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/102718
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Type: Journal article
Title: New genetic loci link adipose and insulin biology to body fat distribution
Author: Shungin, D.
Winkler, T.
Croteau-Chonka, D.
Ferreira, T.
Locke, A.
Mägi, R.
Strawbridge, R.
Pers, T.
Fischer, K.
Justice, A.
Workalemahu, T.
Wu, J.
Buchkovich, M.
Heard-Costa, N.
Roman, T.
Drong, A.
Song, C.
Gustafsson, S.
Day, F.
Esko, T.
et al.
Citation: Nature, 2015; 518(7538):187-197
Publisher: NATURE PUBLISHING GROUP
Issue Date: 2015
ISSN: 0028-0836
1476-4687
Statement of
Responsibility: 
Dimitry Shungin ... Lyle J. Palmer ... et al.
Abstract: Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10⁻⁸). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Keywords: Genome-wide association studies
Rights: © 2015 Macmillan Publishers Limited. All rights reserved
RMID: 0030027037
DOI: 10.1038/nature14132
Appears in Collections:Medicine publications

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