Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/102718
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dc.contributor.authorShungin, D.en
dc.contributor.authorWinkler, T.en
dc.contributor.authorCroteau-Chonka, D.en
dc.contributor.authorFerreira, T.en
dc.contributor.authorLocke, A.en
dc.contributor.authorMägi, R.en
dc.contributor.authorStrawbridge, R.en
dc.contributor.authorPers, T.en
dc.contributor.authorFischer, K.en
dc.contributor.authorJustice, A.en
dc.contributor.authorWorkalemahu, T.en
dc.contributor.authorWu, J.en
dc.contributor.authorBuchkovich, M.en
dc.contributor.authorHeard-Costa, N.en
dc.contributor.authorRoman, T.en
dc.contributor.authorDrong, A.en
dc.contributor.authorSong, C.en
dc.contributor.authorGustafsson, S.en
dc.contributor.authorDay, F.en
dc.contributor.authorEsko, T.en
dc.contributor.authoret al.en
dc.date.issued2015en
dc.identifier.citationNature, 2015; 518(7538):187-197en
dc.identifier.issn0028-0836en
dc.identifier.issn1476-4687en
dc.identifier.urihttp://hdl.handle.net/2440/102718-
dc.description.abstractBody fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10⁻⁸). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.en
dc.description.statementofresponsibilityDimitry Shungin ... Lyle J. Palmer ... et al.en
dc.language.isoenen
dc.publisherNATURE PUBLISHING GROUPen
dc.rights© 2015 Macmillan Publishers Limited. All rights reserveden
dc.subjectGenome-wide association studiesen
dc.titleNew genetic loci link adipose and insulin biology to body fat distributionen
dc.typeJournal articleen
dc.identifier.rmid0030027037en
dc.identifier.doi10.1038/nature14132en
dc.identifier.pubid173410-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medicine publications

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