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Type: Journal article
Title: Wide-field optical coherence microelastography for intraoperative assessment of human breast cancer margins
Author: Allen, W.
Chin, L.
Wijesinghe, P.
Kirk, R.
Latham, B.
Sampson, D.
Saunders, C.
Kennedy, B.
Citation: Biomedical Optics Express, 2016; 7(10):4139-4153
Publisher: Optical Society of America
Issue Date: 2016
ISSN: 2156-7085
Statement of
Wes M. Allen, Lixin Chin, Philip Wijesinghe, Rodney W. Kirk, Bruce Latham, David D. Sampson, Christobel M. Saunders, and Brendan F. Kennedy
Abstract: Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.
Keywords: (110.4500) Optical coherence tomography
(170.0170) Medical optics and biotechnology
Description: Published 19 Sep 2016
Rights: ©2016 Optical Society of America. Open Access - CC BY license.
DOI: 10.1364/BOE.7.004139
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