Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/102839
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Bone-cartilage crosstalk: a conversation for understanding osteoarthritis
Author: Findlay, D.
Kuliwaba, J.
Citation: Bone Research, 2016; 4(1):1-12
Publisher: Nature Publishing Group
Issue Date: 2016
ISSN: 2095-4700
2095-6231
Statement of
Responsibility: 
David M Findlay and Julia S Kuliwaba
Abstract: Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction (crosstalk) between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage, below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are well-described progressive destructive changes in the articular cartilage, which parallel characteristic changes in the underlying bone. This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development.
Rights: © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/
DOI: 10.1038/boneres.2016.28
Appears in Collections:Aurora harvest 7
Medicine publications

Files in This Item:
File Description SizeFormat 
hdl_102839.pdfPublished Version1.01 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.