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Type: Journal article
Title: Red blood cell transfusions at 21 days of age or older in previously transfusion-naive very preterm infants: association with neonatal outcomes
Author: Keir, A.
Aziz, K.
McMillan, D.
Monterrosa, L.
Ojah, C.
Lee, S.
Shah, P.
Citation: American Journal of Perinatology: neonatal and maternal-fetal medicine, 2015; 32(12):1139-1144
Publisher: Thieme
Issue Date: 2015
ISSN: 0735-1631
Statement of
Amy Keir, Khalid Aziz, Douglas McMillan, Luis Monterrosa, Cecil Ojah, Shoo Lee, Prakesh S. Shah, on behalf of the Canadian Neonatal Network
Abstract: This study aims to assess the association of red blood cell (RBC) transfusion in a cohort of preterm infants with mortality, retinopathy of prematurity (ROP), and chronic lung disease (CLD) transfused at ≥21 days of life.This retrospective cohort study included infants born at <30 weeks' gestation who survived ≥21 days, had not received any RBC transfusions before reaching 21 days of age, and were admitted to participating units in the Canadian neonatal network (2003-2009).Out of the 3,799 eligible infants, 3,309 infants did not receive RBC transfusion at  ≥21 days of age, whereas 490 received transfusion at  ≥21 days of age. Infants who did not receive RBC transfusion/s at  ≥21 days of age had higher birth weight (p<0.01) and higher gestational age at the time of birth (p<0.01) as compared with those who received transfusion/s at ≥21 days of age. Receipt of RBC transfusion/s at  ≥21 days of age was not associated with mortality (adjusted odds ratio [AOR] 1.20; 95% confidence interval [CI] 0.33-4.34) or severe ROP (AOR 1.02; 95% CI 0.59-1.77) but was associated with increased odds of CLD (AOR 1.78; 95% CI 1.43-2.22).RBC transfusion/s at  ≥21 days of age in previously transfusion-naive preterm infants was associated with increased odds of CLD but not with ROP or mortality.
Keywords: Infant; newborn; premature; red blood cell transfusion; adverse affects
Rights: Copyright status unknown
DOI: 10.1055/s-0035-1549295
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Paediatrics publications

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