Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/103009
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dc.contributor.authorEspinel-Ingroff, A.en
dc.contributor.authorPfaller, M.en
dc.contributor.authorBustamante, B.en
dc.contributor.authorCanton, E.en
dc.contributor.authorFothergill, A.en
dc.contributor.authorFuller, J.en
dc.contributor.authorGonzalez, G.en
dc.contributor.authorLass-Flörl, C.en
dc.contributor.authorLockhart, S.en
dc.contributor.authorMartin-Mazuelos, E.en
dc.contributor.authorMeis, J.en
dc.contributor.authorMelhem, M.en
dc.contributor.authorOstrosky-Zeichner, L.en
dc.contributor.authorPelaez, T.en
dc.contributor.authorSzeszs, M.en
dc.contributor.authorSt-Germain, G.en
dc.contributor.authorBonfietti, L.en
dc.contributor.authorGuarro, J.en
dc.contributor.authorTurnidge, J.en
dc.date.issued2014en
dc.identifier.citationAntimicrobial Agents and Chemotherapy, 2014; 58(4):2006-2012en
dc.identifier.issn0066-4804en
dc.identifier.issn1098-6596en
dc.identifier.urihttp://hdl.handle.net/2440/103009-
dc.description.abstractAlthough epidemiological cutoff values (ECVs) have been established for Candida spp. and the triazoles, they are based on MIC data from a single laboratory. We have established ECVs for eight Candida species and fluconazole, posaconazole, and voriconazole based on wild-type (WT) MIC distributions for isolates of C. albicans (n=11,241 isolates), C. glabrata (7,538), C. parapsilosis (6,023), C. tropicalis (3,748), C. krusei (1,073), C. lusitaniae (574), C. guilliermondii (373), and C. dubliniensis (162). The 24-h CLSI broth microdilution MICs were collated from multiple laboratories (in Canada, Brazil, Europe, Mexico, Peru, and the United States). The ECVs for distributions originating from ≥6 laboratories, which included ≥95% of the modeled WT population, for fluconazole, posaconazole, and voriconazole were, respectively, 0.5, 0.06 and 0.03 μg/ml for C. albicans, 0.5, 0.25, and 0.03 μg/ml for C. dubliniensis, 8, 1, and 0.25 μg/ml for C. glabrata, 8, 0.5, and 0.12 μg/ml for C. guilliermondii, 32, 0.5, and 0.25 μg/ml for C. krusei, 1, 0.06, and 0.06 μg/ml for C. lusitaniae, 1, 0.25, and 0.03 μg/ml for C. parapsilosis, and 1, 0.12, and 0.06 μg/ml for C. tropicalis. The low number of MICs (<100) for other less prevalent species (C. famata, C. kefyr, C. orthopsilosis, C. rugosa) precluded ECV definition, but their MIC distributions are documented. Evaluation of our ECVs for some species/agent combinations using published individual MICs for 136 isolates (harboring mutations in or upregulation of ERG11, MDR1, CDR1, or CDR2) and 64 WT isolates indicated that our ECVs may be useful in distinguishing WT from non-WT isolates.en
dc.description.statementofresponsibilityA. Espinel-Ingroff, M.A. Pfaller, B. Bustamante, E. Canton, A. Fothergill, J. Fuller, G.M. Gonzalez, C. Lass-Flörl, S.R. Lockhart, E. Martin-Mazuelos, J.F. Meis, M.S.C. Melhem, L. Ostrosky-Zeichner, T. Pelaez, M.W. Szeszs, G. St-Germain, L.X. Bonfietti, J. Guarro, J. Turnidgeen
dc.language.isoEnglishen
dc.publisherAmerican Society for Microbiologyen
dc.rightsCopyright © 2014, American Society for Microbiology. All Rights Reserved.en
dc.subjectCandida; antifungal agentsen
dc.titleMultilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazoleen
dc.typeJournal articleen
dc.identifier.rmid0030030243en
dc.identifier.doi10.1128/AAC.02615-13en
dc.identifier.pubid188308-
pubs.library.collectionMicrobiology and Immunology publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidTurnidge, J. [0000-0003-4240-5578]en
Appears in Collections:Microbiology and Immunology publications

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