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Type: Journal article
Title: Randomized controlled trial of alendronate in airways disease and low bone mineral density
Author: Smith, B.
Laslett, L.
Pile, K.
Phillips, P.
Phillipov, G.
Evans, S.
Esterman, A.
Berry, J.
Citation: Chronic Respiratory Disease, 2004; 1(3):131-137
Publisher: Sage
Issue Date: 2004
ISSN: 1479-9723
Statement of
BJ Smith, LL Laslett, KD Pile, PJ Phillips, G Phillipov, SM Evans, AJ Esterman, and JG Berry
Abstract: BACKGROUND: Patients with airways disease have been demonstrated to be at risk of osteoporosis, and this is likely to be multifactorial. Our aim was to identify patients with low bone mineral density (BMD) using a screening program, and then evaluate the benefit of daily alendronate. METHOD: Subjects with hip or lumbar spine baseline T-scores < - 2.5, or Z-score < - 1.0 commenced on alendronate/calcium (10 mg/600 mg day) or placebo/calcium, in a double blind randomized controlled trial. BMD by dual emission X-ray absorptiometry (lumbar vertebrae 2-4, neck of femur, total femur) was repeated after 12 months, with adverse events recorded. RESULTS: 145 subjects (74 male, 71 female, mean age 67, median FEV1 1.0 litres = 43% of predicted) were enrolled; 66 alendronate/calcium, 79 placebo/calcium with 24 and 26 withdrawals, respectively. Per protocol but not intention to treat analysis of covariance demonstrated statistically significant improvements in T and Z scores for lumbar spine bone mineral density (P = 0.035, P = 0.040), with no improvement demonstrated at the hip. CONCLUSIONS: Improvement in bone mineral density has been demonstrated at the lumbar spine, but not hip, by per protocol analysis, with daily alendronate, at 12 months.
Keywords: Lumbar Vertebrae; Humans; Osteoporosis; Asthma; Pulmonary Disease, Chronic Obstructive; Alendronate; Absorptiometry, Photon; Forced Expiratory Volume; Treatment Outcome; Follow-Up Studies; Bone Density; Aged; Middle Aged; Female; Male; Bone Density Conservation Agents
Rights: © Arnold 2004
RMID: 0030059166
DOI: 10.1191/1479972304cd025oa
Appears in Collections:Medicine publications

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