Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/103053
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Type: Journal article
Title: A multicenter randomized comparison between high-definition white light endoscopy and narrow band imaging for detection of gastric lesions
Author: Ang, T.
Pittayanon, R.
Lau, J.
Rerknimitr, R.
Ho, S.
Singh, R.
Kwek, A.
Ang, D.
Chiu, P.
Luk, S.
Goh, K.
Ong, J.
Tan, J.
Teo, E.
Fock, K.
Citation: European Journal of Gastroenterology and Hepatology, 2015; 27(12):1473-1478
Publisher: Lippincott Williams & Wilkins
Issue Date: 2015
ISSN: 0954-691X
1473-5687
Statement of
Responsibility: 
Tiing Leong Ang, Rapat Pittayanon, James Yun Wong Lau, Rungsun Rerknimitr, Shiaw Hooi Ho, Rajvinder Singh, Andrew Boon Eu Kwek, Daphne Shih Wen Ang, Philip Wai Yan Chiu, Sally Luk, Khean Lee Goh, Jeannie Peng Lan Ong, Jessica Yi-Lyn Tan, Eng Kiong Teo and Kwong Ming Fock
Abstract: Objective Narrow band imaging (NBI) is generally considered to be useful for lesion characterization, but not enhanced detection of gastric lesions, because of the dark endoscopic view. We tested whether the new generation of NBI (190-NBI or 290-NBI), which is twice as bright as the previous version, would improve detection of premalignant gastric lesions compared with high-definition white light endoscopy (HD-WLE). Patients and methods This was a multicenter prospective randomized study involving five tertiary institutions in the Asia-Pacific region. A total of 579 patients aged older than 50 years who underwent diagnostic upper gastrointestinal endoscopy were randomized to either HD-WLE or NBI. The outcome measurements were detection of intestinal metaplasia (IM), focal gastric lesions, and gastric cancers. Results Focal gastric lesions were detected in 83/286 (29%) and 119/293 patients (40.6%) by HD-WLE and by NBI, respectively (P=0.003). IM was detected in 22/286 patients (7.7%) by HD-WLE and in 52/293 patients (17.7%) by NBI (P <0.001). Gastric cancer were found in 7/286 (2.4%) and 3/293 patients (1%) in HD-WLE and NBI groups, respectively (P =0.189). Conclusion NBI increased the detection rate of IM compared with HD-WLE. Eur J Gastroenterol Hepatol 27:1473–1478
Keywords: Gastric; image-enhanced endoscopy; intestinal metaplasia
Rights: Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
DOI: 10.1097/MEG.0000000000000478
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