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|Title:||A network-biology perspective of microRNA function and dysfunction in cancer|
|Citation:||Nature Reviews Genetics, 2016; 17(12):719-732|
|Publisher:||Nature Publishing Group|
|Cameron P. Bracken1, Hamish S. Scott and Gregory J. Goodall|
|Abstract:||MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis, and consequently have roles in many pathologies, including cancer. These small non-coding RNAs exert their effects in the context of complex regulatory networks, often made all the more extensive by the inclusion of transcription factors as their direct targets. In recent years, the increased availability of gene expression data and the development of methodologies that profile miRNA targets en masse have fuelled our understanding of miRNA functions, and of the sources and consequences of miRNA dysregulation. Advances in experimental and computational approaches are revealing not just cancer pathways controlled by single miRNAs but also intermeshed regulatory networks controlled by multiple miRNAs, which often engage in reciprocal feedback interactions with the targets that they regulate.|
|Keywords:||Humans; Neoplasms; MicroRNAs; Gene Expression Profiling; Computational Biology; Models, Genetic; Gene Regulatory Networks|
|Rights:||© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.|
|Appears in Collections:||Medicine publications|
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