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Type: Journal article
Title: Prenatal fish oil supplementation and allergy: 6-year follow-up of a randomized controlled trial
Author: Best, K.P.
Sullivan, T.
Palmer, D.
Gold, M.
Kennedy, D.J.
Martin, J.
Makrides, M.
Citation: Pediatrics, 2016; 137(6):1-9
Publisher: American Academy of Pediatrics
Issue Date: 2016
ISSN: 0031-4005
Statement of
Karen P. Best, Thomas Sullivan, Michael Gold, Declan (John) Kennedy, James Martin, Maria Makrides
Abstract: Background and Objective: Evidence from randomized controlled trials in early infancy suggest that prenatal supplementation with Ω-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease characterized by an immunoglobulin E (IgE) response. We aimed to determine whether protective effects were evident in the 6-year-old offspring of women supplemented with n-3 rich fish oil during pregnancy. Methods: Six-year follow-up of children (n = 706) with a family history of allergic disease from the Docosahexaenoic Acid to Optimize Mother Infant Outcome (DOMInO) trial. Women were randomly allocated to receive n-3 LCPUFA-rich fish oil capsules (800 mg/d docosahexaenoic acid DHA and 100mg/d eicosapentaenoic acid) or vegetable oil capsules (without n-3 LCPUFA). Allergic disease symptoms including eczema, wheeze, rhinitis, and rhino-conjunctivitis, were assessed using the International Study of Asthma and Allergies in Childhood questionnaire and sensitization to allergens was measured by skin prick test. Results: There was no difference in the percentage of children with any IgE-associated allergic disease between the n-3 LCPUFA and control groups (116/367 [31.5%] vs 106/336 [31.5%]; adjusted relative risk, 1.04; 95% confidence interval, 0.82-1.33; P = .73). There was a reduction in the percentage of children sensitized to house dust mite Dermatophagoides farinae (49/367 [13.4%] vs 68/336 [20.3%]; adjusted relative risk, 0.67, 95% confidence interval, 0.44-1.00; P = .0495). Conclusions: Prenatal n-3 LCPUFA supplementation did not reduce IgE-associated allergic disease at 6 years of age. Secondary outcomes were suggestive of a protective effect of the intervention on the incidence of D. farinae sensitization.
Keywords: Animals
Dermatophagoides farinae
Prenatal Exposure Delayed Effects
Docosahexaenoic Acids
Eicosapentaenoic Acid
Immunoglobulin E
Prenatal Care
Follow-Up Studies
Dietary Supplements
Rights: Copyright © 2016 by the American Academy of Pediatrics. All rights reserved.
DOI: 10.1542/peds.2015-4443
Grant ID:
Appears in Collections:Aurora harvest 3
Paediatrics publications

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