Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/10375
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Type: Journal article
Title: Nitric oxide damage to colonocytes in colitis-by-association: Remote transfer of nitric oxide to the colon
Author: Roediger, W.
Citation: Digestion, 2002; 65(4):191-195
Publisher: Karger
Issue Date: 2002
ISSN: 0012-2823
1421-9867
Statement of
Responsibility: 
W.E.W. Roediger
Abstract: New observations of (1) colitis-by-association, (2) the carriage of nitric oxide by haemoglobin, (3) nitric oxide inactivation of CoA, (4) the damage caused to colonocytes by a combination of nitric oxide/sulphide/hydrogen peroxide and (5) colonic extraction of nitric oxide from the circulation, has led to new views on colonocyte damage in colitis. These observations should assist to define initiating factors that lead to release of damaging agents (nitric oxide/hydrogen peroxide) and to delineate protective mechanisms against colonocyte damage. Overall, the production, release, disposal and inactivation of nitric oxide are related to damage to colonocytes and consequent ulceration in colitis.
Keywords: Nitric oxide; Nitrite; Colon; Colitis; Colonocyte; Coenzyme-A; Sulphides
Description: Copyright © 2002 S. Karger AG, Basel
RMID: 0020020647
DOI: 10.1159/000063819
Appears in Collections:Surgery publications

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