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Type: Journal article
Title: Nitric oxide damage to colonocytes in colitis-by-association: Remote transfer of nitric oxide to the colon
Author: Roediger, W.
Citation: Digestion: international journal of gastroenterology, 2002; 65(4):191-195
Publisher: Karger
Issue Date: 2002
ISSN: 0012-2823
Statement of
W.E.W. Roediger
Abstract: New observations of (1) colitis-by-association, (2) the carriage of nitric oxide by haemoglobin, (3) nitric oxide inactivation of CoA, (4) the damage caused to colonocytes by a combination of nitric oxide/sulphide/hydrogen peroxide and (5) colonic extraction of nitric oxide from the circulation, has led to new views on colonocyte damage in colitis. These observations should assist to define initiating factors that lead to release of damaging agents (nitric oxide/hydrogen peroxide) and to delineate protective mechanisms against colonocyte damage. Overall, the production, release, disposal and inactivation of nitric oxide are related to damage to colonocytes and consequent ulceration in colitis.
Keywords: Nitric oxide
Description: Copyright © 2002 S. Karger AG, Basel
DOI: 10.1159/000063819
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Appears in Collections:Aurora harvest 7
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