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https://hdl.handle.net/2440/10375
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Type: | Journal article |
Title: | Nitric oxide damage to colonocytes in colitis-by-association: Remote transfer of nitric oxide to the colon |
Author: | Roediger, W. |
Citation: | Digestion: international journal of gastroenterology, 2002; 65(4):191-195 |
Publisher: | Karger |
Issue Date: | 2002 |
ISSN: | 0012-2823 1421-9867 |
Statement of Responsibility: | W.E.W. Roediger |
Abstract: | New observations of (1) colitis-by-association, (2) the carriage of nitric oxide by haemoglobin, (3) nitric oxide inactivation of CoA, (4) the damage caused to colonocytes by a combination of nitric oxide/sulphide/hydrogen peroxide and (5) colonic extraction of nitric oxide from the circulation, has led to new views on colonocyte damage in colitis. These observations should assist to define initiating factors that lead to release of damaging agents (nitric oxide/hydrogen peroxide) and to delineate protective mechanisms against colonocyte damage. Overall, the production, release, disposal and inactivation of nitric oxide are related to damage to colonocytes and consequent ulceration in colitis. |
Keywords: | Nitric oxide Nitrite Colon Colitis Colonocyte Coenzyme-A Sulphides |
Description: | Copyright © 2002 S. Karger AG, Basel |
DOI: | 10.1159/000063819 |
Published version: | http://dx.doi.org/10.1159/000063819 |
Appears in Collections: | Aurora harvest 7 Surgery publications |
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