Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/103783
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Type: Journal article
Title: Calretinin and parvalbumin in schizophrenia and affective disorders: a mini-review, a perspective on the evolutionary role of calretinin in schizophrenia, and a preliminary post-mortem study of calretinin in the septal nuclei
Author: Brisch, R.
Bielau, H.
Saniotis, A.
Wolf, R.
Bogerts, B.
Krell, D.
Steiner, J.
Braun, K.
Krzyzanowska, M.
Krzyzanowski, M.
Jankowski, Z.
Kaliszan, M.
Bernstein, H.
Gos, T.
Citation: Frontiers in Cellular Neuroscience, 2015; 9(OCTOBER):393-1-393-13
Publisher: Frontiers Media SA
Issue Date: 2015
ISSN: 1662-5102
1662-5102
Statement of
Responsibility: 
Ralf Brisch, Hendrik Bielau, Arthur Saniotis, Rainer Wolf, Bernhard Bogerts, Dieter Krell, Johann Steiner, Katharina Braun, Marta Krzyzanowska Maciej Krzyzanowski, Zbigniew Jankowski, Michał Kaliszan, Hans-Gert Bernstein and Tomasz Gos
Abstract: Objective: The septal nuclei are important limbic regions that are involved in emotional behavior and connect to various brain regions such as the habenular complex. Both the septal nuclei and the habenular complex are involved in the pathology of schizophrenia and affective disorders. Methods: We characterized the number and density of calretinin-immunoreactive neurons in the lateral, medial, and dorsal subregions of the septal nuclei in three groups of subjects: healthy control subjects (N = 6), patients with schizophrenia (N = 10), and patients with affective disorders (N = 6). Results: Our mini-review of the combined role of calretinin and parvalbumin in schizophrenia and affective disorders summarizes 23 studies. We did not observe significant differences in the numbers of calretinin-immunoreactive neurons or neuronal densities in the lateral, medial, and dorsal septal nuclei of patients with schizophrenia or patients with affective disorders compared to healthy control subjects. Conclusions: Most post-mortem investigations of patients with schizophrenia have indicated significant abnormalities of parvalbumin-immunoreactive neurons in various brain regions including the hippocampus, the anterior cingulate cortex, and the prefrontal cortex in schizophrenia. This study also provides an explanation from an evolutionary perspective for why calretinin is affected in schizophrenia.
Keywords: calretinin; parvalbumin; septal nuclei; post-mortem studies; schizophrenia; affective disorders; evolution of the human brain
Rights: © 2015 Brisch, Bielau, Saniotis, Wolf, Bogerts, Krell, Steiner, Braun, Krzyżanowska, Krzyżanowski, Jankowski, Kaliszan, Bernstein and Gos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI: 10.3389/fncel.2015.00393
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