Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/103869
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Type: | Journal article |
Title: | Deciphering the epitranscriptome: a green perspective |
Author: | Burgess, A. David, R. Searle, I. |
Citation: | Journal of Integrative Plant Biology, 2016; 58(10):822-835 |
Publisher: | Wiley-Blackwell |
Issue Date: | 2016 |
ISSN: | 1672-9072 1744-7909 |
Statement of Responsibility: | Alice Burgess, Rakesh David, Iain Robert Searle |
Abstract: | The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome. With over 100 known RNA modifications, understanding the repertoire of RNA modifications is a huge undertaking. This review summarizes what is known about RNA modifications with an emphasis on discoveries in plants. RNA ribose modifications, base methylations and pseudouridylation are required for normal development in Arabidopsis, as mutations in the enzymes modifying them have diverse effects on plant development and stress responses. These modifications can regulate RNA structure, turnover and translation. Transfer RNA and ribosomal RNA modifications have been mapped extensively and their functions investigated in many organisms, including plants. Recent work exploring the locations, functions and targeting of N6 -methyladenosine (m6 A), 5-methylcytosine (m5 C), pseudouridine (Ψ), and additional modifications in mRNAs and ncRNAs are highlighted, as well as those previously known on tRNAs and rRNAs. Many questions remain as to the exact mechanisms of targeting and functions of specific modified sites and whether these modifications have distinct functions in the different classes of RNAs. |
Keywords: | Arabidopsis N6-methyladenosine (m6A) Pseudouridine (Ψ) RNA 5-methylcytosine (m5C) RNA modifications epitranscriptome |
Rights: | © 2016 The Authors. Journal of Integrative Plant Biology Published by John Wiley & Sons Australia, Ltd on behalf of Institute of Botany, Chinese Academy of Sciences. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
DOI: | 10.1111/jipb.12483 |
Grant ID: | http://purl.org/au-research/grants/arc/DP110103805 http://purl.org/au-research/grants/arc/FT130100525 |
Published version: | http://dx.doi.org/10.1111/jipb.12483 |
Appears in Collections: | Aurora harvest 3 Environment Institute publications |
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hdl_103869.pdf | Published version | 886.75 kB | Adobe PDF | View/Open |
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