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Type: Journal article
Title: Directing traffic on DNA - How transcription factors relieve or induce transcriptional interference
Author: Hao, N.
Palmer, A.
Dodd, I.
Shearwin, K.
Citation: Transcription, 2017; 8(2):120-125
Publisher: Taylor and Francis
Issue Date: 2017
ISSN: 2154-1272
Statement of
Nan Hao, Adam C. Palmer, Ian B. Dodd, and Keith E. Shearwin
Abstract: Transcriptional interference (TI) is increasingly recognised as a widespread mechanism of gene control, particularly given the pervasive nature of transcription, both sense and antisense, across all kingdoms of life. Here we discuss how transcription factor binding kinetics strongly influence the ability of a transcription factor to induce or relieve TI.
Keywords: DNA binding kinetics; Transcriptional interference; convergent promoters; dislodgement; roadblock
Rights: © 2017 The Author(s). Published with license by Taylor & Francis.© 2017 Nan Hao, Adam C. Palmer, Ian B. Dodd, and Keith E. Shearwin. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
RMID: 0030063077
DOI: 10.1080/21541264.2017.1285851
Grant ID:
Appears in Collections:Molecular and Biomedical Science publications

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