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|Title:||The obesity associated FTO gene variant and the risk of adverse pregnancy outcomes: evidence from the SCOPE study|
|Citation:||Obesity, 2016; 24(12):2600-2607|
|Prabha H. Andraweera, Gustaaf A. Dekker, Shalem Leemaqz, Lesley McCowan, and Claire T. Roberts (on behalf of the SCOPE consortium)|
|Abstract:||OBJECTIVE: To investigate whether the FTO rs9939609 single nucleotide polymorphism (SNP), which is a risk factor for obesity and vascular diseases, is also associated with pregnancy complications including pre-eclampsia, gestational hypertension, small for gestational age pregnancy (SGA), and spontaneous preterm birth (sPTB). METHODS: A case-control study of 1,741 nulliparous Caucasian women, their partners, and infants was conducted. DNA was extracted from peripheral blood or saliva from parents and cord blood from infants and genotyped using the Sequenom MassARRAY system. RESULTS: The prevalence of maternal and infant AA genotype of FTO rs9939609 was increased in the SGA group compared with the uncomplicated pregnancy group (19.2% vs. 13.4%, OR = 1.7, 95% CI = 1.1-2.6, P = 0.02 and 24.6% vs. 12.5%, OR = 2.7, 95% CI = 1.6-4.6, P = 0.0002). The prevalence of maternal and infant AA genotype of FTO rs9939609 was also increased in the sPTB group compared with the uncomplicated pregnancy group (20.8% vs. 13.4%, OR = 2.1, 95% CI = 1.2-3.8, P = 0.009 and 20.0% vs. 12.5%, OR = 2.4, 95% CI = 1.0-5.3, P = 0.03). CONCLUSIONS: The maternal and infant AA genotype of the obesity associated FTO rs9939609 SNP associates with increased risk for SGA and sPTB. This SNP may be important in predicting the risk of these pregnancy complications and subsequent vascular diseases.|
|Keywords:||SCOPE consortium; Humans; Pregnancy Complications; Hypertension, Pregnancy-Induced; Pre-Eclampsia; Obesity; Pregnancy Outcome; Case-Control Studies; Pregnancy; Genotype; Adult; Infant, Newborn; Infant, Small for Gestational Age; Female; Alpha-Ketoglutarate-Dependent Dioxygenase FTO|
|Rights:||© 2016 The Obesity Society|
|Appears in Collections:||Medicine publications|
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