Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/10391
Type: Journal article
Title: Expression of TGF-beta and its receptors in murine fetal and adult dermal wounds
Author: Cowin, A.
Holmes, T.
Brosnan, P.
Ferguson, M.
Citation: European Journal of Dermatology, 2001; 11(5):424-431
Publisher: John Libbey Eurotext Ltd
Issue Date: 2001
ISSN: 1167-1122
1952-4013
Statement of
Responsibility: 
Allison J. Cowin, Toby M. Holmes, Patricia Brosan, Mark W.J. Ferguson
Abstract: The transforming growth factor-betas (TGF-betas) are of major importance in wound healing and have been implicated in the scar-less wound repair observed in fetuses. Few studies have characterised the role of TGF-beta in fetal wound repair and to date no studies have characterised the expression of its receptors within non-scarring fetal wounds. We have localised the TGF-beta isoforms beta1, beta2 and beta3 and its two receptors, TGF-betaRI and TGF-betaRII in both adult and fetal dermal murine wounds. We observed low level immunofluorescence of TGF-beta1 and TGF-beta2 in fetal wounds and although TGF-beta3 staining was observed in the epidermis of fetal skin, there was no upregulation in response to injury. By contrast, all three isoforms were strongly expressed in adult wounds. Similar to its ligands, TGF-beta receptor expression was increased post-wounding in the adult wounds. However, in contrast, no mRNA or protein for either of the TGF-beta receptors was observed in response to wounding in the fetal dermis although there was both mRNA and protein expression of both the receptors localised within the fetal alimentary tract, one of the few fetal organs which does scar post-injury. The differences that we observed in the expression of TGF-beta and its receptors in adult and fetal wounds could be important in the absence of scar formation that is observed in the fetus.
Keywords: in situ hybridisation; fetal; TGF-beta; receptor; wound healing
Rights: Copyright © 2007 John Libbey Eurotext - All rights reserved
RMID: 0020011154
Appears in Collections:Surgery publications

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