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Type: Journal article
Title: Smart surface-enhanced Raman scattering traceable drug delivery systems
Author: Liu, L.
Tang, Y.
Dai, S.
Kleitz, F.
Qiao, S.
Citation: Nanoscale, 2016; 8(25):12803-12811
Publisher: Royal Society of Chemistry
Issue Date: 2016
ISSN: 2040-3364
Statement of
Lei Liu, Yonghong Tang, Sheng Dai, Freddy Kleitz and Shi Zhang Qiao
Abstract: A novel smart nanoparticle-based system has been developed for tracking intracellular drug delivery through surface-enhanced Raman scattering (SERS). This new drug delivery system (DDS) shows targeted cytotoxicity towards cancer cells via pH-cleavable covalent carboxylic hydrazone links and the SERS tracing capability based on gold@silica nanocarriers. Doxorubicin, as a model anticancer drug, was employed to compare SERS with conventional fluorescence tracing approaches. It is evident that SERS demonstrates higher sensitivity and resolution, revealing intracellular details, as the strengths of the original Raman signals can be amplified by SERS. Importantly, non-destructive SERS will provide the designed DDS with great autonomy and potential to study the dynamic procedures of non-fluorescent drug delivery into living cells.
Keywords: Hela Cells; Humans; Gold; Doxorubicin; Drug Delivery Systems; Spectrum Analysis, Raman; Metal Nanoparticles; HEK293 Cells; Drug Liberation
Rights: This journal is © The Royal Society of Chemistry 2016. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
RMID: 0030050865
DOI: 10.1039/c6nr03869g
Grant ID:
Appears in Collections:Chemistry and Physics publications

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