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|Title:||"Thunderstruck": plasma-polymer-coated porous silicon microparticles ss a controlled drug delivery system|
|Citation:||ACS Applied Materials and Interfaces, 2016; 8(7):4467-4476|
|Publisher:||American Chemical Society|
|Steven J. P. McInnes, Thomas D. Michl, Bahman Delalat, Sameer A. Al-Bataineh, Bryan R. Coad, Krasimir Vasilev, Hans J. Griesser, and Nicolas H. Voelcker|
|Abstract:||Controlling the release kinetics from a drug carrier is crucial to maintain a drug’s therapeutic window. We report the use of biodegradable porous silicon microparticles (pSi MPs) loaded with the anticancer drug camphothecin, followed by a plasma polymer overcoating using a loudspeaker plasma reactor. Homogenous “Teflon-like” coatings were achieved by tumbling the particles by playing AC/DC’s song “Thunderstruck”. The overcoating resulted in a markedly slower release of the cytotoxic drug, and this effect correlated positively with the plasma polymer coating times, ranging from 2-fold up to more than 100-fold. Ultimately, upon characterizing and verifying pSi MP production, loading, and coating with analytical methods such as time-of-flight secondary ion mass spectrometry, scanning electron microscopy, thermal gravimetry, water contact angle measurements, and fluorescence microscopy, human neuroblastoma cells were challenged with pSi MPs in an in vitro assay, revealing a significant time delay in cell death onset.|
|Keywords:||Plasma polymerization; fluorinated coating; particle coating; porous silicon; controlled drug release|
|Description:||Published: February 2, 2016|
|Rights:||© 2016 American Chemical Society|
|Appears in Collections:||Agriculture, Food and Wine publications|
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