Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/104176
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Type: Journal article
Title: Inter-regulation of gastric emptying and incretin hormone secretion: implications for postprandial glycemic control
Author: Wu, T.
Rayner, C.
Horowitz, M.
Citation: Biomarkers in Medicine, 2016; 10(11):1167-1179
Publisher: Future Medicine Ltd.
Issue Date: 2016
ISSN: 1752-0363
1752-0371
Statement of
Responsibility: 
Tongzhi Wu, Christopher K Rayner, Michael Horowitz
Abstract: The GI tract is central to the regulation of postprandial glycemia, with the rate of gastric emptying and the secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, being key determinants. Gastric emptying exhibits a large interindividual variation; the latter not only accounts for differences in postprandial glycemia but also determines postprandial incretin profiles. Accordingly, the rate of gastric emptying may affect the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors. In contrast, glucagon-like peptide-1 receptor agonists lower postprandial glycemia predominantly by their action to slow gastric emptying. This review discusses the inter-relationship between gastric emptying and the incretin axis in the context of changes in blood glucose, with an emphasis on the relevant clinical implications.
Keywords: dietary intervention
Rights: Copyright status unknown
RMID: 0030057212
DOI: 10.2217/bmm-2016-0164
Appears in Collections:Medicine publications

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