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Type: Journal article
Title: Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease
Author: Chen, T.
Xie, N.
Viglianti, L.
Zhou, Y.
Tan, H.
Tang, B.
Tang, Y.
Citation: Faraday Discussions, 2017; 196:351-362
Publisher: Royal Society of Chemistry
Issue Date: 2017
ISSN: 1359-6640
Statement of
Tong Chen, Lucia Viglianti, Yabin Zhou, Hui Tan, Ben Zhong Tang and Youhong Tang
Abstract: Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved. In addition, BSPOTPE, a reported excellent AIE bioprobe for human serum albumin (HSA) quantitation, is used together with IDATPE in artificial urine for UACR testing. The mutual interference of HSA and creatinine when the bioprobes are used for quantitation is characterised, with promising results. Further improvements and potential applications in CKD quantitation are highlighted.
Keywords: Humans
Fluorescent Dyes
Molecular Structure
Renal Insufficiency, Chronic
Serum Albumin, Human
Description: First published on 05 Sep 2016
Rights: Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
DOI: 10.1039/c6fd00153j
Appears in Collections:Animal and Veterinary Sciences publications
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