Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/10462
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Type: Journal article
Title: Palliation of pancreatic cancer using electrolytic ablation
Author: Wemyss-Holden, S.
Court, F.
Morrison, C.
Teague, B.
Burrell, A.
Morales, D.
Rodgers, N.
Anthony, A.
Metcalfe, M.
Dennison, A.
Maddern, G.
Citation: Surgical Endoscopy-Ultrasound and Interventional Techniques, 2003; 17(2):207-211
Publisher: Springer-Verlag
Issue Date: 2003
ISSN: 0930-2794
1432-2218
Statement of
Responsibility: 
S.A. Wemyss-Holden, F.G. Court, C.P. Morrison, B.D. Teague, A. Burrell, D.R. Morales, N. Rodgers, A.A Anthony, M.S. Metcalfe, A.R. Dennison and G.J. Maddern
Abstract: Background: Inoperable pancreatic cancer has a dismal prognosis. Palliation involves either stenting or surgical bypass. Stenting does not relieve gastric outlet obstruction, and surgical bypass is a major procedure. A minimally invasive procedure is needed that relieves both gastric outlet and biliary obstruction, with the potential for relieving pain. Methods: In an experimental model, pancreatic electrolysis was investigated. The pancreatic duct was cannulated via a transduodenal approach with an electrode catheter. In 6 animals an electrolytic "lesion" was created using a direct current generator. Six animals were controls. The local and systemic effects of electrolysis were assessed using histological and biochemical parameters. Results: The pancreatic duct was cannulated in all animals and treatment was uneventful. Electrolytic lesions comprised a central area of necrosis with a sharp demarcation between necrotic and viable pancreas. All animals developed transient hyperamylasemia after electrolysis. There was no significant difference between treatment and controls. Importantly, no animal had clinical, biochemical, or histological evidence of pancreatitis. Conclusions: This experimental study suggested that electrolytic palliation of inoperable pancreatic cancer via the gastrointestinal tract is potentially safe. In patients, this treatment could be performed during endoscopic retrograde cholangiopancreatography and may have therapeutic advantages when compared to stenting or biliary bypass.
Keywords: Pancreas; Animals; Swine; Pancreatic Neoplasms; Necrosis; Amylases; C-Reactive Protein; Catheter Ablation; Treatment Outcome; Palliative Care; Laparotomy; Feasibility Studies; Female
Description: The original publication is available at www.springerlink.com
RMID: 0020030332
DOI: 10.1007/s00464-002-9109-y
Appears in Collections:Surgery publications

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