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Type: Journal article
Title: New susceptibility loci associated with kidney disease in type 1 diabetes
Author: Sandholm, N.
Salem, R.
McKnight, A.
Brennan, E.
Forsblom, C.
Isakova, T.
McKay, G.
Williams, W.
Sadlier, D.
Mäkinen, V.
Swan, E.
Palmer, C.
Boright, A.
Ahlqvist, E.
Deshmukh, H.
Keller, B.
Huang, H.
Ahola, A.
Fagerholm, E.
Gordin, D.
et al.
Citation: PLoS Genetics, 2012; 8(9):e1002921-1-e1002921-13
Publisher: Public Library of Science
Issue Date: 2012
ISSN: 1553-7390
Editor: Böger, C.A.
Statement of
Niina Sandholm ... Ville-Petteri Mäkinen ... et al.
Abstract: Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to the decrease in the quality of life, DN accounts for a large proportion of the excess mortality associated with type 1 diabetes (T1D). Whereas the degree of glycemia plays a pivotal role in DN, a subset of individuals with poorly controlled T1D do not develop DN. Furthermore, strong familial aggregation supports genetic susceptibility to DN. However, the genes and the molecular mechanisms behind the disease remain poorly understood, and current therapeutic strategies rarely result in reversal of DN. In the GEnetics of Nephropathy: an International Effort (GENIE) consortium, we have undertaken a meta-analysis of genome-wide association studies (GWAS) of T1D DN comprising ∼2.4 million single nucleotide polymorphisms (SNPs) imputed in 6,691 individuals. After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2×10⁻⁸) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0×10⁻⁹). Functional data suggest that AFF3 influences renal tubule fibrosis via the transforming growth factor-beta (TGF-β1) pathway. The strongest association with DN as a primary phenotype was seen for an intronic SNP in the ERBB4 gene (rs7588550, P = 2.1×10⁷), a gene with type 2 diabetes DN differential expression and in the same intron as a variant with cis-eQTL expression of ERBB4. All these detected associations represent new signals in the pathogenesis of DN.
Keywords: Kidney Disease; type 1 diabetes
Rights: © 2012 Sandholm et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pgen.1002921
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Molecular and Biomedical Science publications

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