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|Title:||Perductal electrolytic ablation of the porcine pancreas|
|Citation:||Surgical Endoscopy-Ultrasound and Interventional Techniques, 2004; 18(10):1435-1441|
|C.P. Morrison, F.G. Court, S.A. Wemyss-Holden, B. D. Teague, A. Burrell, M. Texler, M.S. Metcalfe, A.R. Dennison and G.J. Maddern|
|Abstract:||Background: Pancreatic cancer has a dismal prognosis. Few patients are suitable for surgical resection, leaving the majority requiring symptom palliation. Current palliative techniques such as surgical bypass and endoscopic retrograde cholangiopancreatography (ERCP) are imperfect. A novel palliative therapy combining the symptom control of surgical bypass with the minimally invasive nature of ERCP is required. Methods: Perductal electrolytic ablation of pancreatic tissue, in a porcine model, was performed. There were two survival groups of 2 weeks (n = 4) and 8 weeks (n = 4). Postoperatively, serum biochemistry, amylase and C-reactive protein (CRP) were assessed. Histological examination of the pancreas, lungs, and kidneys was performed to determine the presence of acute pancreatitis or systemic inflammatory response. Results: An immediate transient increase in both amylase and CRP was seen. Although pancreatic histology demonstrated localised necrosis at the electrolytic site at 2 weeks, there was no evidence of generalized pancreatitis or a systemic inflammatory response at either 2 or 8 weeks. Conclusions: This study suggests that, although there is localized pancreatic necrosis and transient hyperamylasemia, perductal pancreatic electrolytic ablation is safe, with neither generalized pancreatitis nor a systemic inflammatory response, in the medium and long term. Although performed in normal porcine pancreas, because of the absence of a large-animal model of pancreatic cancer, this study suggests that electrolytic pancreatic ablation is safe. This technique may have a role in the palliation of pancreatic cancer, especially if delivered via a minimally, invasive approach, and warrants further investigation.|
|Keywords:||Pancreas; Electrolysis; Local ablation; Palliation; Experimental studies|
|Description:||The original publication is available at www.springerlink.com|
|Appears in Collections:||Surgery publications|
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