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dc.contributor.authorBachhuka, A.-
dc.contributor.authorHayball, J.-
dc.contributor.authorSmith, L.-
dc.contributor.authorVasilev, K.-
dc.identifier.citationACS Applied Materials and Interfaces, 2015; 7(42):23767-23775-
dc.description.abstractSurface modification has been identified as an important technique that could improve the response of the body to implanted medical devices. Collagen production by fibroblasts is known to play a vital role in wound healing and device fibrous encapsulation. However, how surface chemistry affects collagen I and III deposition by these cells has not been systematically studied. Here, we report how surface chemistry influences the deposition of collagen I and III by primary human dermal fibroblasts. Amine (NH3), carboxyl acid (COOH), and hydrocarbon (CH3) surfaces were generated by plasma deposition. This is a practically relevant tool to deposit a functional coating on any type of substrate material. We show that fibroblasts adhere better and proliferate faster on amine-rich surfaces. In addition, the initial collagen I and III production is greater on this type of coating. These data indicates that surface modification can be a promising route for modulating the rate and level of fibrous encapsulation and may be useful in informing the design of implantable biomedical devices to produce more predictable clinical outcomes.-
dc.description.statementofresponsibilityAkash Bachhuka, John Hayball, Louise E. Smith and K. Vasilev-
dc.publisherAmerican Chemical Society-
dc.rights© 2015 American Chemical Society-
dc.subjectplasma polymerization; surface chemistry; collagen I; collagen III; fibroblasts-
dc.titleEffect of surface chemical functionalities on collagen deposition by primary human dermal fibroblasts-
dc.typeJournal article-
dc.identifier.orcidBachhuka, A. [0000-0003-1253-8126]-
dc.identifier.orcidHayball, J. [0000-0002-3089-4506]-
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Physics publications

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