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https://hdl.handle.net/2440/104845
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dc.contributor.author | Bachhuka, A. | - |
dc.contributor.author | Hayball, J. | - |
dc.contributor.author | Smith, L. | - |
dc.contributor.author | Vasilev, K. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | ACS Applied Materials and Interfaces, 2015; 7(42):23767-23775 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.issn | 1944-8252 | - |
dc.identifier.uri | http://hdl.handle.net/2440/104845 | - |
dc.description.abstract | Surface modification has been identified as an important technique that could improve the response of the body to implanted medical devices. Collagen production by fibroblasts is known to play a vital role in wound healing and device fibrous encapsulation. However, how surface chemistry affects collagen I and III deposition by these cells has not been systematically studied. Here, we report how surface chemistry influences the deposition of collagen I and III by primary human dermal fibroblasts. Amine (NH3), carboxyl acid (COOH), and hydrocarbon (CH3) surfaces were generated by plasma deposition. This is a practically relevant tool to deposit a functional coating on any type of substrate material. We show that fibroblasts adhere better and proliferate faster on amine-rich surfaces. In addition, the initial collagen I and III production is greater on this type of coating. These data indicates that surface modification can be a promising route for modulating the rate and level of fibrous encapsulation and may be useful in informing the design of implantable biomedical devices to produce more predictable clinical outcomes. | - |
dc.description.statementofresponsibility | Akash Bachhuka, John Hayball, Louise E. Smith and K. Vasilev | - |
dc.language.iso | en | - |
dc.publisher | American Chemical Society | - |
dc.rights | © 2015 American Chemical Society | - |
dc.source.uri | http://dx.doi.org/10.1021/acsami.5b08249 | - |
dc.subject | plasma polymerization; surface chemistry; collagen I; collagen III; fibroblasts | - |
dc.title | Effect of surface chemical functionalities on collagen deposition by primary human dermal fibroblasts | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1021/acsami.5b08249 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP150104212 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Bachhuka, A. [0000-0003-1253-8126] | - |
dc.identifier.orcid | Hayball, J. [0000-0002-3089-4506] | - |
Appears in Collections: | Aurora harvest 8 Physics publications |
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