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Type: Journal article
Title: Immunohistochemical labeling of normal melanocytes
Author: Dean, N.
Brennan, J.
Haynes, J.
Goddard, C.
Cooter, R.
Citation: Applied Immunohistochemistry and Molecular Morphology, 2002; 10(3):199-204
Publisher: Lippincott Williams & Wilkins
Issue Date: 2002
ISSN: 1541-2016
Abstract: Comparison of seven antibodies for the demonstration of normal melanocytes in formalin-fixed, paraffin-embedded surgical discard skin showed that the monoclonal antibody Mel-5 (clone TA99) directed against pigment associated antigen was the most sensitive. Quantitative data were obtained for the sensitivity of the antibodies NKI/beteb, S100, T311, Melan A (clone A103), c-kit, and Mel-5 in parallel sections of human skin. An anticytokeratin antibody (CK34betaE12) was also used to stain basal keratinocytes and provide a negative image of the melanocytes present. Optimal conditions for the use of Mel-5 in paraffin sections of skin are described.
Keywords: Keratinocytes
S100 Proteins
Neoplasm Proteins
Antibodies, Monoclonal
Antigens, Neoplasm
Sensitivity and Specificity
Proto-Oncogene Proteins c-kit
Melanoma-Specific Antigens
MART-1 Antigen
Description: Copyright © 2002 Lippincott Williams & Wilkins, Inc.
DOI: 10.1097/00022744-200209000-00002
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Appears in Collections:Aurora harvest 7
Surgery publications

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