Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/10491
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dc.contributor.authorHuilgol, S.-
dc.contributor.authorSelva-Nayagam, D.-
dc.contributor.authorChen, C.-
dc.contributor.authorHill, D.-
dc.contributor.authorJames, C.-
dc.contributor.authorGramp, A.-
dc.contributor.authorMalhotra, R.-
dc.date.issued2004-
dc.identifier.citationArchives of Dermatology, 2004; 140(9):1087-1092-
dc.identifier.issn0003-987X-
dc.identifier.issn1538-3652-
dc.identifier.urihttp://hdl.handle.net/2440/10491-
dc.description.abstract<h4>Objectives</h4>To assess the margins required for excision of lentigo maligna (LM) and lentigo maligna melanoma (LMM) by the technique of mapped serial excision (MSE), and to assess the efficacy of MSE.<h4>Design</h4>An interventional, prospective, noncontrolled case series.<h4>Setting</h4>Tertiary referral, dermatologic surgery unit.<h4>Patients</h4>Consecutive patients with head and neck LM or LMM who underwent MSE between March 1, 1993, and October 31, 2002.<h4>Intervention</h4>The MSE of LM or LMM.<h4>Main outcome measures</h4>The number of 5-mm levels for excision of LM and LMM and recurrence.<h4>Results</h4>One hundred sixty-one LMs or LMMs in 155 patients were treated. Thirty percent (37 of 125) of LMs required more than 5-mm margins. For LMMs less than 1 mm in Breslow thickness, 12% (4/32) required more than 10-mm margins. For primary tumors, 20% of LMs (18 of 91) required more than 5-mm margins, while 10% of LMMs less than 1 mm in Breslow thickness (2 of 21) required more than a 10-mm margin. For recurrent tumors, 56% of LMs (19/34) required more than a 5-mm margin. Mean follow-up of 38 months (range, 5-100 months) showed 4 recurrences (2%) after MSE. The extrapolated recurrence at 5 years was 5.0%.<h4>Conclusions</h4>The current recommendations of 5-mm margins for LM and 10-mm margins for LMM less than 1 mm in Breslow thickness are often insufficient. Our results demonstrate the importance of margin-controlled excision, particularly in recurrent lesions. The use of MSE offers a high cure rate, in conjunction with tissue conservation.-
dc.language.isoen-
dc.publisherAmer Medical Assoc-
dc.source.urihttp://dx.doi.org/10.1001/archderm.140.9.1087-
dc.subjectHumans-
dc.subjectMelanoma-
dc.subjectHutchinson's Melanotic Freckle-
dc.subjectSkin Neoplasms-
dc.subjectNeoplasm Recurrence, Local-
dc.subjectNeoplasm Staging-
dc.subjectTreatment Outcome-
dc.subjectMohs Surgery-
dc.subjectReoperation-
dc.subjectConfidence Intervals-
dc.subjectProbability-
dc.subjectRisk Assessment-
dc.subjectSensitivity and Specificity-
dc.subjectStatistics, Nonparametric-
dc.subjectCohort Studies-
dc.subjectFollow-Up Studies-
dc.subjectProspective Studies-
dc.subjectAdult-
dc.subjectAged-
dc.subjectAged, 80 and over-
dc.subjectMiddle Aged-
dc.subjectFemale-
dc.subjectMale-
dc.titleSurgical margins for lentigo maligna and lentigo maligna melanoma - The technique of mapped serial excision-
dc.typeJournal article-
dc.identifier.doi10.1001/archderm.140.9.1087-
pubs.publication-statusPublished-
dc.identifier.orcidHuilgol, S. [0000-0001-6668-1230]-
dc.identifier.orcidSelva-Nayagam, D. [0000-0002-2169-5417]-
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Surgery publications

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