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Type: Journal article
Title: Antibiotic tolerance and the alternative lifestyles of Staphylococcus aureus
Author: Bui, L.M.
Conlon, B.P.
Kidd, S.P.
Citation: Essays in Biochemistry, 2017; 61(1):71-79
Publisher: Portland Press
Issue Date: 2017
ISSN: 0071-1365
Editor: Venter, H.
Statement of
Long M.G. Bui, Brian P. Conlon and Stephen P. Kidd
Abstract: Staphylococcus aureus has an incredible ability to survive, either by adapting to environmental conditions or defending against exogenous stress. Although there are certainly important genetic traits, in part this ability is provided by the breadth of modes of growth S. aureus can adopt. It has been proposed that while within their host, S. aureus survives host-generated and therapeutic antimicrobial stress via alternative lifestyles: a persister sub-population, through biofilm growth on host tissue or by growing as small colony variants (SCVs). Key to an understanding of chronic and relapsing S. aureus infections is determining the molecular basis for its switch to these quasi-dormant lifestyles. In a multicellular biofilm, the metabolically quiescent bacterial community additionally produces a highly protective extracellular polymeric substance (EPS). Furthermore, there are bacteria within a biofilm community that have an altered physiology potentially equivalent to persister cells. Recent studies have directly linked the cellular ATP production by persister cells as their key feature and the basis for their tolerance of a range of antibiotics. In clinical settings, SCVs of S. aureus have been observed for many years; when cultured, these cells form non-pigmented colonies and are approximately ten times smaller than their counterparts. Various genotypic factors have been identified in attempts to characterize S. aureus SCVs and different environmental stresses have been implicated as important inducers.
Keywords: Staphylococcus aureus
Staphylococcal Infections
Anti-Bacterial Agents
Drug Resistance, Bacterial
Energy Metabolism
Stress, Physiological
Description: Version of Record published: 3 March 2017
Rights: © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
DOI: 10.1042/EBC20160061
Published version:
Appears in Collections:Aurora harvest 3
Molecular and Biomedical Science publications

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