Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/105047
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Type: Journal article
Title: Matching meals to body clocks-impact on weight and glucose metabolism
Author: Hutchison, A.
Wittert, G.
Heilbronn, L.
Citation: Nutrients, 2017; 9(3):222-1-222-10
Publisher: Multidisciplinary Digital Publishing Institute
Issue Date: 2017
ISSN: 2072-6643
2072-6643
Statement of
Responsibility: 
Amy T. Hutchison, Gary A. Wittert and Leonie K. Heilbronn
Abstract: The prevalence of type 2 diabetes continues to rise worldwide and is reaching pandemic proportions. The notion that this is due to obesity, resulting from excessive energy consumption and reduced physical activity, is overly simplistic. Circadian de-synchrony, which occurs when physiological processes are at odds with timing imposed by internal clocks, also promotes obesity and impairs glucose tolerance in mouse models, and is a feature of modern human lifestyles. The purpose of this review is to highlight what is known about glucose metabolism in animal and human models of circadian de-synchrony and examine the evidence as to whether shifts in meal timing contribute to impairments in glucose metabolism, gut hormone secretion and the risk of type 2 diabetes. Lastly, we examine whether restricting food intake to discrete time periods, will prevent or reverse abnormalities in glucose metabolism with the view to improving metabolic health in shift workers and in those more generally at risk of chronic diseases such as type 2 diabetes and cardiovascular disease.
Keywords: chronic disease risk
circadian rhythm
glucose metabolism
time-restricted feeding
type 2 diabetes
Rights: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI: 10.3390/nu9030222
Grant ID: http://purl.org/au-research/grants/arc/FT120100027
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