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Type: Journal article
Title: Nitroxidative signaling mechanisms in pathological pain
Author: Grace, P.
Gaudet, A.
Staikopoulos, V.
Maier, S.
Hutchinson, M.
Salvemini, D.
Watkins, L.
Citation: Trends in Neurosciences, 2016; 39(12):862-879
Publisher: Elsevier
Issue Date: 2016
ISSN: 0166-2236
Statement of
Peter M. Grace, Andrew D. Gaudet, Vasiliki Staikopoulos, Steven F. Maier, Mark R. Hutchinson, Daniela Salvemini and Linda R. Watkins
Abstract: Tissue injury can initiate bidirectional signaling between neurons, glia, and immune cells that creates and amplifies pain. While the ability for neurotransmitters, neuropeptides, and cytokines to initiate and maintain pain has been extensively studied, recent work has identified a key role for reactive oxygen and nitrogen species (ROS/RNS; nitroxidative species), including superoxide, peroxynitrite, and hydrogen peroxide. In this review we describe how nitroxidative species are generated after tissue injury and the mechanisms by which they enhance neuroexcitability in pain pathways. Finally, we discuss potential therapeutic strategies for normalizing nitroxidative signaling, which may also enhance opioid analgesia, to help to alleviate the enormous burden of pathological pain.
Keywords: NADPH oxidase
Rights: © 2016 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.tins.2016.10.003
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Appears in Collections:Aurora harvest 3
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