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Type: Journal article
Title: The role of CC-chemokines in the regulation of angiogenesis
Author: Ridiandries, A.
Tan, J.
Bursill, C.
Citation: International Journal of Molecular Sciences, 2016; 17(11):1856-1-1856-16
Publisher: MDPI AG
Issue Date: 2016
ISSN: 1661-6596
Statement of
Anisyah Ridiandries, Joanne T. M. Tan and Christina A. Bursill
Abstract: Angiogenesis, the formation of new blood vessels, is critical for survival and in the regenerative response to tissue injury or ischemia. However, in diseases such as cancer and atherosclerosis, inflammation can cause unregulated angiogenesis leading to excessive neovascularization, which exacerbates disease. Current anti-angiogenic therapies cause complete inhibition of both inflammatory and ischemia driven angiogenesis causing a range of side effects in patients. Specific inhibition of inflammation-driven angiogenesis would therefore be immensely valuable. Increasing evidence suggests that the CC-chemokine class promotes inflammation-driven angiogenesis,whilst there is little evidence for a role in ischemia-mediated angiogenesis. The differential regulation of angiogenesis by CC-chemokines suggests it may provide an alternate strategy to treat angiogenesis associated pathological diseases. The focus of this review is to highlight the significant role of the CC-chemokine class in inflammation, versus ischemia driven angiogenesis, and to discuss the related pathologies including atherosclerosis, cancer, and rheumatoid arthritis. We examine the pros and cons of anti-angiogenic therapies currently in clinical trials. We also reveal novel therapeutic strategies that cause broad-spectrum inhibition of the CC-chemokine class that may have future potential for the specific inhibition of inflammatory angiogenesis.
Keywords: angiogenesis; chemokines; inflammation; ischemia
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (
RMID: 0030067739
DOI: 10.3390/ijms17111856
Grant ID:
Appears in Collections:Medicine publications

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