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Type: Journal article
Title: Molecular genetics of B-precursor acute lymphoblastic leukemia
Author: Mullighan, C.
Citation: Journal of Clinical Investigation, 2012; 122(10):3407-3415
Publisher: American Society for Clinical Investigation
Issue Date: 2012
ISSN: 0021-9738
Statement of
Charles G. Mullighan
Abstract: B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and the leading cause of cancer-related death in children and young adults. The majority of B-ALL cases are aneuploid or harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of disease. Recent studies have used microarrays and sequencing to comprehensively identify all somatic genetic alterations in acute lymphoblastic leukemia (ALL). These studies have identified cryptic or submicroscopic genetic alterations that define new ALL subtypes, cooperate with known chromosomal rearrangements, and influence prognosis. This article reviews these advances, discusses results from ongoing second-generation sequencing studies of ALL, and highlights challenges and opportunities for future genetic profiling approaches.
Keywords: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Rights: Copyright © 2012, The American Society for Clinical Investigation.
RMID: 0030061224
DOI: 10.1172/JCI61203
Appears in Collections:Medicine publications

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