Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/105348
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dc.contributor.authorWong, S.en
dc.contributor.authorLidums, I.en
dc.contributor.authorRosty, C.en
dc.contributor.authorRuszkiewicz, A.en
dc.contributor.authorParry, S.en
dc.contributor.authorWin, A.en
dc.contributor.authorTomita, Y.en
dc.contributor.authorVatandoust, S.en
dc.contributor.authorTownsend, A.en
dc.contributor.authorPatel, D.en
dc.contributor.authorHardingham, J.en
dc.contributor.authorRoder, D.en
dc.contributor.authorSmith, E.en
dc.contributor.authorDrew, P.en
dc.contributor.authorMarker, J.en
dc.contributor.authorUylaki, W.en
dc.contributor.authorHewett, P.en
dc.contributor.authorWorthley, D.en
dc.contributor.authorSymonds, E.en
dc.contributor.authorYoung, G.en
dc.contributor.authoret al.en
dc.date.issued2017en
dc.identifier.citationBMC Gastroenterology, 2017; 17(1):56-1-56-9en
dc.identifier.issn1471-230Xen
dc.identifier.issn1471-230Xen
dc.identifier.urihttp://hdl.handle.net/2440/105348-
dc.description.abstractBackground: Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this work was to document the prevalence and histological subtype of lesions seen in patients aged <50 years, and any associated clinical features. Methods: An audit of the colonoscopy database at The Queen Elizabeth Hospital in Adelaide, South Australia over a 12-month period was undertaken. Findings were recorded from both colonoscopy reports and corresponding histological examination of excised lesions. Results: Data were extracted from colonoscopies in 2064 patients. Those aged <50 comprised 485 (24%) of the total. CRC precursor lesions (including sessile serrated adenoma/polyps (SSA/P), traditional serrated adenomas, tubular adenomas ≥10 mm or with high-grade dysplasia, and conventional adenomas with villous histology) were seen in 4.3% of patients aged <50 and 12.9% of patients aged ≥50 (P <0.001). Among colonoscopies yielding CRC precursor lesions in patients under 50 years, SSA/P occurred in 52% of procedures (11/21), compared with 27% (55/204) of procedures in patients aged 50 and older (P = 0.02). SSA/P were proximally located in (10/11) 90% of patients aged under 50, and 80% (43/54) of those aged 50 and older (P = 0.46). Conclusions: SSA/P were the most frequently observed CRC precursor lesions in patients aged <50. Most CRCs in this age group are known to arise in the distal colon and rectum suggesting that lesions other than SSA/P may serve as the precursor for the majority of early-onset CRC.en
dc.description.statementofresponsibilityStephanie Wong, Ilmars Lidums, Christophe Rosty, Andrew Ruszkiewicz, Susan Parry, Aung Ko Win, Yoko Tomita, Sina Vatandoust, Amanda Townsend, Dainik Patel, Jennifer E. Hardingham, David Roder, Eric Smith, Paul Drew, Julie Marker, Wendy Uylaki, Peter Hewett, Daniel L. Worthley, Erin Symonds, Graeme P. Young, Timothy J. Price and Joanne P. Youngen
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rights© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectAdenoma; Early-onset colorectal cancer; Sessile serrated adenomaen
dc.titleFindings in young adults at colonoscopy from a hospital service database auditen
dc.typeJournal articleen
dc.identifier.rmid0030068565en
dc.identifier.doi10.1186/s12876-017-0612-yen
dc.identifier.pubid348920-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRuszkiewicz, A. [0000-0001-9052-4948]en
dc.identifier.orcidTomita, Y. [0000-0001-7934-2203]en
dc.identifier.orcidTownsend, A. [0000-0003-3563-4719]en
dc.identifier.orcidHardingham, J. [0000-0001-8277-1199]en
dc.identifier.orcidRoder, D. [0000-0001-6442-4409]en
dc.identifier.orcidSmith, E. [0000-0003-2958-3492]en
dc.identifier.orcidDrew, P. [0000-0001-5661-4771]en
dc.identifier.orcidWorthley, D. [0000-0003-0374-9124]en
dc.identifier.orcidPrice, T. [0000-0002-3922-2693]en
dc.identifier.orcidYoung, J. [0000-0002-1514-1522]en
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