Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/105353
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dc.contributor.author | Morrisroe, K. | - |
dc.contributor.author | Stevens, W. | - |
dc.contributor.author | Sahhar, J. | - |
dc.contributor.author | Rabusa, C. | - |
dc.contributor.author | Nikpour, M. | - |
dc.contributor.author | Proudman, S. | - |
dc.contributor.author | Hill, C. | - |
dc.contributor.author | Lester, S. | - |
dc.contributor.author | Rischmueller, M. | - |
dc.contributor.author | Walker, J. | - |
dc.contributor.author | Nash, P. | - |
dc.contributor.author | Ngian, G. | - |
dc.contributor.author | Roddy, J. | - |
dc.contributor.author | Strickland, G. | - |
dc.contributor.author | Thakkar, V. | - |
dc.contributor.author | Zochling, J. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Arthritis Research and Therapy, 2017; 19(1):42-1-42-10 | - |
dc.identifier.issn | 1478-6354 | - |
dc.identifier.issn | 1478-6362 | - |
dc.identifier.uri | http://hdl.handle.net/2440/105353 | - |
dc.description.abstract | Pulmonary arterial hypertension (PAH) is the leading cause of death in systemic sclerosis (SSc). Annual screening with echocardiogram (ECHO) is recommended. We present the methodological aspects of a PAH screening programme in a large Australian SSc cohort, the epidemiology of SSc-PAH in this cohort, and an evaluation of factors influencing physician adherence to PAH screening guidelines.Patient characteristics and results of PAH screening were determined in all patients enrolled in a SSc longitudinal cohort study. Adherence to PAH screening guidelines was assessed by a survey of Australian rheumatologists. Summary statistics, chi-square tests, univariate and multivariable logistic regression were used to determine the associations of risk factors with PAH.Among 1636 patients with SSc, 194 (11.9%) had PAH proven by right-heart catheter. Of these, 160 were detected by screening. The annual incidence of PAH was 1.4%. Patients with PAH diagnosed on subsequent screens, compared with patients in whom PAH was diagnosed on first screen, were more likely to have diffuse SSc (p = 0.03), be in a better World Health Organisation (WHO) Functional Class at PAH diagnosis (p = 0.01) and have less advanced PAH evidenced by higher mean six-minute walk distance (p = 0.03), lower mean pulmonary arterial pressure (p = 0.009), lower mean pulmonary vascular resistance (p = 0.006) and fewer non-trivial pericardial effusions (p = 0.03). Adherence to annual PAH screening using an ECHO-based algorithm was poor among Australian rheumatologists, with less than half screening their patients with SSc of more than ten years disease duration.PAH is a common complication of SSc. Physician adherence to PAH screening recommendations remains poor. Identifying modifiable barriers to screening may improve adherence and ultimately patient outcomes. | - |
dc.description.statementofresponsibility | Kathleen Morrisroe, Wendy Stevens, Joanne Sahhar, Candice Rabusa, Mandana Nikpour, Susanna Proudman and the Australian Scleroderma Interest Group (ASIG) | - |
dc.language.iso | en | - |
dc.publisher | BioMed Central | - |
dc.rights | © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | - |
dc.source.uri | http://dx.doi.org/10.1186/s13075-017-1250-z | - |
dc.subject | Australian Scleroderma Interest Group (ASIG) | - |
dc.subject | Systemic sclerosis; scleroderma; pulmonary arterial hypertension; screening algorithm | - |
dc.title | Epidemiology and disease characteristics of systemic sclerosis-related pulmonary arterial hypertension: results from a real-life screening programme | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1186/s13075-017-1250-z | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1113954 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1071735 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Proudman, S. [0000-0002-3046-9884] | - |
dc.identifier.orcid | Hill, C. [0000-0001-8289-4922] | - |
dc.identifier.orcid | Lester, S. [0000-0003-3013-2701] | - |
dc.identifier.orcid | Rischmueller, M. [0000-0001-5057-3286] | - |
Appears in Collections: | Aurora harvest 8 Public Health publications |
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