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Type: Journal article
Title: Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging
Author: Wedding, J.
Harris, H.
Bader, C.
Plush, S.
Mak, R.
Massi, M.
Brooks, D.
Lai, B.
Vogt, S.
Werrett, M.
Simpson, P.
Skelton, B.
Stagni, S.
Citation: Metallomics: integrated biometal science, 2017; 9(4):382-390
Publisher: Royal Society of Chemistry
Issue Date: 2017
ISSN: 1756-5901
Statement of
J. L. Wedding, H. H. Harris, C. A. Bader, S. E. Plush, R. Mak, M. Massi, D. A. Brooks, B. Lai, S. Vogt, M. V. Werrett, P. V. Simpson, B. W. Skelton and S. Stagni
Abstract: Optical epifluorescence microscopy was used in conjunction with X-ray fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO)3(phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells. The rhenium complex showed no signs of ancillary ligand dissociation, a conclusion based on data obtained via X-ray fluorescence imaging aligning iodine and rhenium distributions. A diffuse reticular localisation was detected for the complex in the nuclear/perinuclear region of cells, by either optical or X-ray fluorescence imaging techniques. X-ray fluorescence also showed that the rhenium complex disrupted the homeostasis of some biologically relevant elements, such as chlorine, potassium and zinc.
Keywords: Cell Line, Tumor
Luminescent Agents
Microscopy, Fluorescence
Coordination Complexes
Optical Imaging
Rights: This journal is©The Royal Society of Chemistry 2017
DOI: 10.1039/c6mt00243a
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