Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/105703
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging
Author: Wedding, J.
Harris, H.
Bader, C.
Plush, S.
Mak, R.
Massi, M.
Brooks, D.
Lai, B.
Vogt, S.
Werrett, M.
Simpson, P.
Skelton, B.
Stagni, S.
Citation: Metallomics: integrated biometal science, 2017; 9(4):382-390
Publisher: Royal Society of Chemistry
Issue Date: 2017
ISSN: 1756-5901
1756-591X
Statement of
Responsibility: 
J. L. Wedding, H. H. Harris, C. A. Bader, S. E. Plush, R. Mak, M. Massi, D. A. Brooks, B. Lai, S. Vogt, M. V. Werrett, P. V. Simpson, B. W. Skelton and S. Stagni
Abstract: Optical epifluorescence microscopy was used in conjunction with X-ray fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO)3(phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells. The rhenium complex showed no signs of ancillary ligand dissociation, a conclusion based on data obtained via X-ray fluorescence imaging aligning iodine and rhenium distributions. A diffuse reticular localisation was detected for the complex in the nuclear/perinuclear region of cells, by either optical or X-ray fluorescence imaging techniques. X-ray fluorescence also showed that the rhenium complex disrupted the homeostasis of some biologically relevant elements, such as chlorine, potassium and zinc.
Keywords: Cell Line, Tumor
Humans
Rhenium
Tetrazoles
Phenanthrolines
Luminescent Agents
Microscopy, Fluorescence
X-Rays
Coordination Complexes
Optical Imaging
Rights: This journal is©The Royal Society of Chemistry 2017
DOI: 10.1039/c6mt00243a
Grant ID: http://purl.org/au-research/grants/arc/DP140100176
http://purl.org/au-research/grants/arc/FT130100033
Appears in Collections:Aurora harvest 3
Chemistry publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.