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https://hdl.handle.net/2440/105703
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Type: | Journal article |
Title: | Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging |
Author: | Wedding, J.L. Harris, H.H. Bader, C.A. Plush, S.E. Mak, R. Massi, M. Brooks, D.A. Lai, B. Vogt, S. Werrett, M.V. Simpson, P.V. Skelton, B.W. Stagni, S. |
Citation: | Metallomics: integrated biometal science, 2017; 9(4):382-390 |
Publisher: | Royal Society of Chemistry |
Issue Date: | 2017 |
ISSN: | 1756-5901 1756-591X |
Statement of Responsibility: | J. L. Wedding, H. H. Harris, C. A. Bader, S. E. Plush, R. Mak, M. Massi, D. A. Brooks, B. Lai, S. Vogt, M. V. Werrett, P. V. Simpson, B. W. Skelton and S. Stagni |
Abstract: | Optical epifluorescence microscopy was used in conjunction with X-ray fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO)3(phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells. The rhenium complex showed no signs of ancillary ligand dissociation, a conclusion based on data obtained via X-ray fluorescence imaging aligning iodine and rhenium distributions. A diffuse reticular localisation was detected for the complex in the nuclear/perinuclear region of cells, by either optical or X-ray fluorescence imaging techniques. X-ray fluorescence also showed that the rhenium complex disrupted the homeostasis of some biologically relevant elements, such as chlorine, potassium and zinc. |
Keywords: | Cell Line, Tumor Humans Rhenium Tetrazoles Phenanthrolines Luminescent Agents Microscopy, Fluorescence X-Rays Coordination Complexes Optical Imaging |
Rights: | This journal is©The Royal Society of Chemistry 2017 |
DOI: | 10.1039/c6mt00243a |
Grant ID: | http://purl.org/au-research/grants/arc/DP140100176 http://purl.org/au-research/grants/arc/FT130100033 |
Published version: | http://dx.doi.org/10.1039/c6mt00243a |
Appears in Collections: | Aurora harvest 3 Chemistry publications |
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