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|Title:||Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging|
|Citation:||Metallomics: integrated biometal science, 2017; 9(4):382-390|
|Publisher:||Royal Society of Chemistry|
|J. L. Wedding, H. H. Harris, C. A. Bader, S. E. Plush, R. Mak, M. Massi, D. A. Brooks, B. Lai, S. Vogt, M. V. Werrett, P. V. Simpson, B. W. Skelton and S. Stagni|
|Abstract:||Optical epifluorescence microscopy was used in conjunction with X-ray fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO)3(phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells. The rhenium complex showed no signs of ancillary ligand dissociation, a conclusion based on data obtained via X-ray fluorescence imaging aligning iodine and rhenium distributions. A diffuse reticular localisation was detected for the complex in the nuclear/perinuclear region of cells, by either optical or X-ray fluorescence imaging techniques. X-ray fluorescence also showed that the rhenium complex disrupted the homeostasis of some biologically relevant elements, such as chlorine, potassium and zinc.|
|Keywords:||Cell Line, Tumor|
|Rights:||This journal is©The Royal Society of Chemistry 2017|
|Appears in Collections:||Aurora harvest 3|
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