Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/105742
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Type: Journal article
Title: Measuring and tracking vitamin B12: a review of current methods with a focus on optical spectroscopy
Author: Tsiminis, G.
Schartner, E.
Brooks, J.
Hutchinson, M.
Citation: Applied Spectroscopy Reviews, 2017; 52(5):439-455
Publisher: Taylor & Francis
Issue Date: 2017
ISSN: 0570-4928
1520-569X
Statement of
Responsibility: 
Georgios Tsiminis, Erik P. Schartner, Joanna L. Brooks, and Mark R. Hutchinson
Abstract: Vitamin B12 deficiency has been associated with an increased risk of cognitive decline. This literature review explores the current methods available for measuring vitamin B12 in human blood, serum, and urine, and the need for a globally accepted reference range for vitamin B12. We present optical spectroscopy, including chemiluminescence measurements, absorption and fluorescence spectroscopy, surface plasmon resonance, and Raman spectroscopy, as a promising technique for detection and tracking of vitamin B12. Considerations for future research are highlighted, including enhancing the sensitivity of optical spectroscopy and prospective pathways to improve the reproducibility, selectivity, and speed of vitamin B12 detection.
Keywords: Biophotonics; cognitive ageing; dementia; optical sensor; sensing; vitamin; vitamin B12
Description: Published online: 13 Sep 2016
Rights: © 2017 G. Tsiminis, E. P. Schartner, J. L. Brooks, and M. R. Hutchinson. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
RMID: 0030065068
DOI: 10.1080/05704928.2016.1229325
Appears in Collections:IPAS publications

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