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dc.contributor.authorTsiminis, G.en
dc.contributor.authorSchartner, E.en
dc.contributor.authorBrooks, J.en
dc.contributor.authorHutchinson, M.en
dc.identifier.citationApplied Spectroscopy Reviews, 2017; 52(5):439-455en
dc.descriptionPublished online: 13 Sep 2016en
dc.description.abstractVitamin B12 deficiency has been associated with an increased risk of cognitive decline. This literature review explores the current methods available for measuring vitamin B12 in human blood, serum, and urine, and the need for a globally accepted reference range for vitamin B12. We present optical spectroscopy, including chemiluminescence measurements, absorption and fluorescence spectroscopy, surface plasmon resonance, and Raman spectroscopy, as a promising technique for detection and tracking of vitamin B12. Considerations for future research are highlighted, including enhancing the sensitivity of optical spectroscopy and prospective pathways to improve the reproducibility, selectivity, and speed of vitamin B12 detection.en
dc.description.statementofresponsibilityGeorgios Tsiminis, Erik P. Schartner, Joanna L. Brooks, and Mark R. Hutchinsonen
dc.publisherTaylor & Francisen
dc.rights© 2017 G. Tsiminis, E. P. Schartner, J. L. Brooks, and M. R. Hutchinson. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.en
dc.subjectBiophotonics; cognitive ageing; dementia; optical sensor; sensing; vitamin; vitamin B12en
dc.titleMeasuring and tracking vitamin B12: a review of current methods with a focus on optical spectroscopyen
dc.typeJournal articleen
pubs.library.collectionIPAS publicationsen
Appears in Collections:IPAS publications

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