Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/105752
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Type: Journal article
Title: Subjective well-being in older adults: folate and vitamin B₁₂ independently predict positive affect
Author: Edney, L.
Burns, N.
Danthiir, V.
Citation: British Journal of Nutrition, 2015; 114(8):1321-1328
Publisher: Cambridge University Press
Issue Date: 2015
ISSN: 0007-1145
1475-2662
Statement of
Responsibility: 
Laura C. Edney, Nicholas R. Burns and Vanessa Danthiir
Abstract: Vitamin B₁₂, folate and homocysteine have long been implicated in mental illness, and growing evidence suggests that they may play a role in positive mental health. Elucidation of these relationships is confounded due to the dependence of homocysteine on available levels of vitamin B₁₂ and folate. Cross-sectional and longitudinal relationships between vitamin B₁₂, folate, homocysteine and subjective well-being were assessed in a sample of 391 older, community-living adults without clinically diagnosed depression. Levels of vitamin B₁₂, but not folate, influenced homocysteine levels 18 months later. Vitamin B₁₂, folate and their interaction significantly predicted levels of positive affect (PA) 18 months later, but had no impact on the levels of negative affect or life satisfaction. Cross-sectional relationships between homocysteine and PA were completely attenuated in the longitudinal analyses, suggesting that the cross-sectional relationship is driven by the dependence of homocysteine on vitamin B₁₂ and folate. This is the first study to offer some evidence of a causal link between levels of folate and vitamin B₁₂ on PA in a large, non-clinical population.
Keywords: Folate; homocysteine; positive affect; subjective well-being; vitamin B12
Rights: © The Authors 2015
RMID: 0030035031
DOI: 10.1017/S0007114515002949
Grant ID: http://purl.org/au-research/grants/nhmrc/578800
Appears in Collections:Psychology publications

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