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|Title:||¹⁸FDG PET CT imaging in the diagnosis and monitoring of large vessel vasculitis|
|Other Titles:||(18)FDG PET CT imaging in the diagnosis and monitoring of large vessel vasculitis|
|Citation:||Internal Medicine Journal, 2016; 46(Suppl. 1):33|
|T Crowhurst, R Dobson, L Nguyen, D Bartholomeusz, C Hill|
|Abstract:||Background: Large vessel vasculitis (LVV) is an autoimmune inﬂamma- tory disease of large vessels. Diagnosis and monitoring can be challenging. Traditionally clinical review, inﬂ ammatory markers and angiography /computed tomography (CT) have been utilised to identify the destructive results of vessel inﬂammation. Positron emission tomography (PET) with 18-ﬂuorodeoxyglucose (18FDG) can provide additional information including active large vessel inﬂammation in the context of otherwise reassuring clinical, biochemical and radiology data. Aim: To investigate the clinical utili ty of 18 FDG PET for the detection and management of vasculitis in a hospital setting. Method: A retrospect ive audit of adult patients who had PET between 1 August 2010 and 31 August 2015 where the term ‘vasculitis’ was utilised in the scan report. Case notes, laboratory and radiologic data was audited. Information was collected on the initial diagnosis, any change in diag nosis, histologic data, inﬂammatory markers, treatment including doses of immunosuppression, correlative imaging and clinical symptoms and signs as documented at outpatient appointments. Results: 67 patients were identiﬁed (66% Female), 13 were excluded due to inaccessible follow-up. Patients were referred for suspected LVV 41% (22/54 ), known LVV 15% (8/54), Pyrexia of Unknown Origin 15% (8/54), increased inﬂammatory markers 9% (5/54), known malignancy 4% (2/54) and other 16% (9/54). PET was positive for LVV in 17% (9/54) of patients, equivocal in 4% (2/54) and negative in 79% (43/53). 56% of pos itive patients were referred for suspected LVV, 22% with known LVV, and 22% as an incidental ﬁnding after investigation of a known malignancy. Conclusion: In this diverse patient group, PET scans were positive for vasculitis in a high proportion of patients with suspected or known LVV (78%). PET imaging has a potential role in the diagnosis of LVV for patients where vasculitis is suspected but not conclusive from routine clinical investigation.|
|Rights:||© 2016 The Authors Internal Medicine Journal © 2016 Royal Australasian College of Physicians|
|Appears in Collections:||Medicine publications|
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