Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/105825
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Associations of mortality and cardiovascular disease risks with diabetes and albuminuria in urban Indigenous Australians: the DRUID follow-up study |
Author: | Barr, E. Cunningham, J. Tatipata, S. Dunbar, T. Kangaharan, N. Guthridge, S. Li, S. Condon, J. Shaw, J. O'Dea, K. Maple-Brown, L. |
Citation: | Diabetic Medicine, 2017; 34(7):946-957 |
Publisher: | Wiley/Blackwell |
Issue Date: | 2017 |
ISSN: | 0742-3071 1464-5491 |
Statement of Responsibility: | E. L. M. Barr, J. Cunningham, S. Tatipata, T. Dunbar, N. Kangaharan, S. Guthridge, S. Q. Li, J. R. Condon, J. E. Shaw, K. O, Dea and L. J. Maple-Brown |
Abstract: | Aim: To assess the relationships of diabetes and albuminuria with all-cause mortality and cardiovascular disease outcomes in a population without prior cardiovascular disease using data from the Darwin Region Urban Indigenous Diabetes (DRUID) study. Methods: We conducted a prospective cohort study of 706 participants (aged 15-81 years, 68% women) without prior cardiovascular disease who underwent a 75-g oral glucose tolerance test. Deaths and fatal or non-fatal cardiovascular disease were determined over 7 years, and hazard ratios with 95% CIs and population attributable risks were estimated for baseline glycaemia and albuminuria. Results: Compared with normoglycaemia and after adjustment for age, sex, hypertension, dyslipidaemia and smoking, known diabetes was associated with an adjusted hazard ratio of 4.8 (95% CI 1.5-14.7) for all-cause mortality and 5.6 (95% CI 2.1-15.2) for cardiovascular disease. Compared with normoalbuminuria, the respective adjusted risks for macroalbuminuria were 10.9 (95% CI 3.7-32.1) and 3.9 (95% CI 1.4-10.8). The Adjusted all-cause mortality and cardiovascular disease estimated population attributable risks for diabetes were 27% and 32%, and for albuminuria they were 32% and 21%, respectively. Conclusions: In our study population, the burden of mortality and cardiovascular disease was largely driven by diabetes and albuminuria. This finding on the influence of diabetes and albuminuria is consistent with reports in other high-risk Indigenous populations and should be better reflected in risk scores and intervention programmes. |
Keywords: | Humans Diabetic Nephropathies Albuminuria Cardiovascular Diseases Diabetic Angiopathies Health Surveys Incidence Prevalence Mortality Proportional Hazards Models Risk Factors Cohort Studies Follow-Up Studies Prospective Studies Adolescent Adult Aged Urban Health Australia Female Male Renal Insufficiency, Chronic Diabetic Cardiomyopathies Native Hawaiian or Other Pacific Islander |
Description: | Accepted 28 March 2017. Special Issue on Diabetes Epidemiology |
Rights: | © 2017 Diabetes UK |
DOI: | 10.1111/dme.13360 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1016612 http://purl.org/au-research/grants/nhmrc/1058244 http://purl.org/au-research/grants/nhmrc/545200 http://purl.org/au-research/grants/nhmrc/1078477 http://purl.org/au-research/grants/nhmrc/1079438 http://purl.org/au-research/grants/nhmrc/236207 |
Published version: | http://dx.doi.org/10.1111/dme.13360 |
Appears in Collections: | Aurora harvest 3 Public Health publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.