Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/10602
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Type: Journal article
Title: Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1H MRS at 1.5 T
Author: Stanwell, P.
Gluch, L.
Clark, D.
Tomanek, B.
Baker, L.
Giuffre, B.
Lean, C.
Malycha, P.
Mountford, C.
Citation: European Radiology, 2005; 15(5):1037-1043
Publisher: Springer-Verlag
Issue Date: 2005
ISSN: 0938-7994
1432-1084
Statement of
Responsibility: 
Peter Stanwell, Laurence Gluch, David Clark, Boguslaw Tomanek, Luke Baker, Bruno Giuffrè, Cynthia Lean, Peter Malycha, Carolyn Mountford
Abstract: The purpose was to determine if in vivo proton magnetic resonance spectroscopy ((1)H MRS) at 1.5 T can accurately provide the correct pathology of breast disease. Forty-three asymptomatic volunteers including three lactating mothers were examined and compared with 21 breast cancer patients. Examinations were undertaken at 1.5 T using a purpose-built transmit-receive single breast coil. Single voxel spectroscopy was undertaken using echo times of 135 and 350 ms. The broad composite resonance at 3.2 ppm, which includes contributions from choline, phosphocholine (PC), glycerophosphocholine (GPC), myo-inositol and taurine, was found not to be a unique marker for malignancy providing a diagnostic sensitivity and specificity of 80.0 and 86.0%, respectively. This was due to three of the asymptomatic volunteers and all of the lactating mothers also generating the broad composite resonance at 3.2 ppm. Optimised post-acquisitional processing of the spectra resolved a resonance at 3.22 ppm, consistent with PC, in patients with cancer. In contrast the spectra recorded for three false-positive volunteers, and the three lactating mothers had a resonance centred at 3.28 ppm (possibly taurine, myo-inositol or GPC). This improved the specificity of the test to 100%. Careful referencing of the spectra and post-acquisitional processing intended to optimise spectral resolution of in vivo MR proton spectra from human breast tissue resolves the composite choline resonance. This allows the distinction of patients with malignant disease from volunteers with a sensitivity of 80% and specificity of 100%. Therefore, resolution of the composite choline resonance into its constituent components improves the specificity of the in vivo (1)H MRS method, but does not overcome the problem of 20% false-negatives.
Keywords: Humans; Breast Neoplasms; Choline; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Sensitivity and Specificity; Case-Control Studies; Predictive Value of Tests; Signal Processing, Computer-Assisted; Adult; Aged; Middle Aged; Female
RMID: 0020041913
DOI: 10.1007/s00330-004-2475-1
Appears in Collections:Surgery publications

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