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Type: Journal article
Title: Randomized controlled trial of early regular egg intake to prevent egg allergy
Author: Palmer, D.
Sullivan, T.
Gold, M.
Prescott, S.
Makrides, M.
Citation: Journal of Allergy and Clinical Immunology, 2017; 139(5):1600-1600
Publisher: Elsevier
Issue Date: 2017
ISSN: 0091-6749
Statement of
Debra J. Palmer, Thomas R. Sullivan, Michael S. Gold, Susan L. Prescott, Maria Makrides
Abstract: Background: The ideal age to introduce egg into the infant diet has been debated for the past 2 decades in the context of rising rates of egg allergy. Objective: We sought to determine whether regular consumption of egg protein from age 4 to 6 months reduces the risk of IgE-mediated egg allergy in infants with hereditary risk, but without eczema. Methods: Infants aged 4 to 6 months were randomly allocated to receive daily pasteurized raw whole egg powder (n = 407) or a color-matched rice powder (n = 413) to age 10 months. All infants followed an egg-free diet and cooked egg was introduced to both groups at age 10 months. The primary outcome was IgE-mediated egg allergy defined by a positive pasteurized raw egg challenge and egg sensitization at age 12 months. Results: There was no difference between groups in the percentage of infants with IgE-mediated egg allergy (egg 7.0% vs control 10.3%; adjusted relative risk, 0.75; 95% CI, 0.48-1.17; P = .20). A higher proportion of participants in the egg group stopped taking the study powder because of a confirmed allergic reaction (25 of 407 [6.1%] compared with 6 of 413 [1.5%]). Egg-specific IgG4 levels were substantially higher in the egg group at 12 months (median, 1.22 mgA/L vs control 0.07 mgA/L; P < .0001). Conclusions: We found no evidence that regular egg intake from age 4 to 6 months substantially alters the risk of egg allergy by age 1 year in infants who are at hereditary risk of allergic disease and had no eczema symptoms at study entry.
Keywords: Allergy prevention
complementary feeding
food allergy
hereditary risk
oral tolerance
randomized controlled trial
Rights: © 2016 American Academy of Allergy, Asthma & Immunology
DOI: 10.1016/j.jaci.2016.06.052
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