Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/106130
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dc.contributor.authorPalmer, D.-
dc.contributor.authorSullivan, T.-
dc.contributor.authorGold, M.-
dc.contributor.authorPrescott, S.-
dc.contributor.authorMakrides, M.-
dc.date.issued2017-
dc.identifier.citationJournal of Allergy and Clinical Immunology, 2017; 139(5):1600-1600-
dc.identifier.issn0091-6749-
dc.identifier.issn1097-6825-
dc.identifier.urihttp://hdl.handle.net/2440/106130-
dc.description.abstractBackground: The ideal age to introduce egg into the infant diet has been debated for the past 2 decades in the context of rising rates of egg allergy. Objective: We sought to determine whether regular consumption of egg protein from age 4 to 6 months reduces the risk of IgE-mediated egg allergy in infants with hereditary risk, but without eczema. Methods: Infants aged 4 to 6 months were randomly allocated to receive daily pasteurized raw whole egg powder (n = 407) or a color-matched rice powder (n = 413) to age 10 months. All infants followed an egg-free diet and cooked egg was introduced to both groups at age 10 months. The primary outcome was IgE-mediated egg allergy defined by a positive pasteurized raw egg challenge and egg sensitization at age 12 months. Results: There was no difference between groups in the percentage of infants with IgE-mediated egg allergy (egg 7.0% vs control 10.3%; adjusted relative risk, 0.75; 95% CI, 0.48-1.17; P = .20). A higher proportion of participants in the egg group stopped taking the study powder because of a confirmed allergic reaction (25 of 407 [6.1%] compared with 6 of 413 [1.5%]). Egg-specific IgG4 levels were substantially higher in the egg group at 12 months (median, 1.22 mgA/L vs control 0.07 mgA/L; P < .0001). Conclusions: We found no evidence that regular egg intake from age 4 to 6 months substantially alters the risk of egg allergy by age 1 year in infants who are at hereditary risk of allergic disease and had no eczema symptoms at study entry.-
dc.description.statementofresponsibilityDebra J. Palmer, Thomas R. Sullivan, Michael S. Gold, Susan L. Prescott, Maria Makrides-
dc.language.isoen-
dc.publisherElsevier-
dc.rights© 2016 American Academy of Allergy, Asthma & Immunology-
dc.subjectAllergy prevention-
dc.subjectcomplementary feeding-
dc.subjectegg-
dc.subjectfood allergy-
dc.subjecthereditary risk-
dc.subjectoral tolerance-
dc.subjectrandomized controlled trial-
dc.titleRandomized controlled trial of early regular egg intake to prevent egg allergy-
dc.typeJournal article-
dc.identifier.doi10.1016/j.jaci.2016.06.052-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/626805-
pubs.publication-statusPublished-
dc.identifier.orcidGold, M. [0000-0003-1312-5331]-
dc.identifier.orcidMakrides, M. [0000-0003-3832-541X]-
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