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Type: Journal article
Title: Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure
Author: Kennedy, B.
Mclaughlin, R.
Kennedy, K.
Chin, L.
Curatolo, A.
Tien, A.
Latham, B.
Saunders, C.
Sampson, D.
Citation: Biomedical Optics Express, 2014; 5(7):2113-2124
Publisher: Optical Society of America
Issue Date: 2014
ISSN: 2156-7085
Statement of
Brendan F. Kennedy, Robert A. McLaughlin, Kelsey M. Kennedy, Lixin Chin, Andrea Curatolo, Alan Tien, Bruce Latham, Christobel M. Saunders and David D. Sampson
Abstract: We present optical coherence micro-elastography, an improved form of compression optical coherence elastography. We demonstrate the capacity of this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. We use phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading. Optical coherence micro-elastography incorporates common-path interferometry, weighted averaging of the complex OCT signal and weighted least-squares regression. Using three-dimensional phase unwrapping, we have increased the maximum detectable strain eleven-fold over no unwrapping and the minimum detectable strain is 2.6 με. We demonstrate the potential of mechanical over optical contrast for visualizing micro-scale tissue structures in human breast cancer pathology and lymph node morphology.
Keywords: (100.5088) Phase unwrapping
(110.1650) Coherence imaging
(110.4500) Optical coherence tomography
Rights: © 2014 Optical Society of America
DOI: 10.1364/BOE.5.002113
Grant ID: ARC
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