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Type: Journal article
Title: Parametric imaging of viscoelasticity using optical coherence elastography
Author: Wijesinghe, P.
McLaughlin, R.
Sampson, D.
Kennedy, B.
Citation: Physics in Medicine and Biology, 2015; 60(6):2293-2307
Publisher: IOP Publishing
Issue Date: 2015
ISSN: 0031-9155
Statement of
Philip Wijesinghe, Robert A McLaughlin, David D Sampson and Brendan F Kennedy
Abstract: We demonstrate imaging of soft tissue viscoelasticity using optical coherence elastography. Viscoelastic creep deformation is induced in tissue using step-like compressive loading and the resulting time-varying deformation is measured using phase-sensitive optical coherence tomography. From a series of co-located B-scans, we estimate the local strain rate as a function of time, and parameterize it using a four-parameter Kelvin-Voigt model of viscoelastic creep. The estimated viscoelastic strain and time constant are used to visualize viscoelastic creep in 2D, dual-parameter viscoelastograms. We demonstrate our technique on six silicone tissue-simulating phantoms spanning a range of viscoelastic parameters. As an example in soft tissue, we report viscoelastic contrast between muscle and connective tissue in fresh, ex vivo rat gastrocnemius muscle and mouse abdominal transection. Imaging viscoelastic creep deformation has the potential to provide complementary contrast to existing imaging modalities, and may provide greater insight into disease pathology.
Keywords: Viscoelastic creep; biomechanical properties; optical coherence elastography
Rights: © 2015 Institute of Physics and Engineering in Medicine
DOI: 10.1088/0031-9155/60/6/2293
Grant ID: ARC
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