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https://hdl.handle.net/2440/106228
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Type: | Journal article |
Title: | Prenatal antidepressant exposure and child behavioural outcomes at 7 years of age: a study within the Danish National Birth Cohort |
Author: | Grzeskowiak, L. Morrison, J. Henriksen, T. Bech, B. Obel, C. Olsen, J. Pedersen, L. |
Citation: | BJOG: an International Journal of Obstetrics and Gynaecology, 2016; 123(12):1919-1928 |
Publisher: | Blackwell Publishing |
Issue Date: | 2016 |
ISSN: | 1470-0328 1471-0528 |
Statement of Responsibility: | LE Grzeskowiak, JL Morrison, TB Henrikse, BH Bech, C Obel, J Olsen, LH Pedersen |
Abstract: | Objective: To investigate the impact of prenatal antidepressant exposure on behavioural problems in children at 7 years of age. Design: Nationwide population-based study. Setting: Danish National Birth Cohort. Population: A cohort of 49 178 pregnant women recruited between 1996 and 2002. Methods: Data obtained from computer-assisted telephone interviews twice during pregnancy were used to identify children born to: (i) depressed women who took antidepressants during pregnancy (n = 210); (ii) depressed women who did not take any antidepressants during pregnancy (n = 231); and (iii) healthy women who were not depressed (n = 48 737). Childhood behavioural problems at 7 years of age were examined using the validated Danish parent-report version of the Strengths and Difficulties Questionnaire (SDQ). Main outcome measures: SDQ scores. Results: No associations were observed between prenatal antidepressant exposure and abnormal SDQ scores for overall problem behaviour (adjusted relative risk, aRR 1.00; 95% confidence interval, 95% CI 0.49–2.05), hyperactivity/inattention (aRR 0.99; 95% CI 0.56–1.75), or peer problems (aRR 1.04; 95% CI 0.57–1.91). Although prenatal antidepressant exposure appeared to be associated with abnormal SDQ scores on the subscales of emotional symptoms (aRR 1.68; 95% CI 1.18–2.38) and conduct problems (aRR 1.58; 95% CI 1.03–2.42), these associations were significantly attenuated following adjustment for antenatal mood status (aRR 1.20; 95% CI 0.85–1.70 and aRR 1.19; 95% CI 0.77 1.83, respectively). Untreated prenatal depression was associated with an increased risk of all behavioural outcomes evaluated, compared with unexposed children, with significant attenuation following adjustment for antenatal mood status. Conclusions: The results of this study suggest that independent of maternal illness, prenatal antidepressant exposure is not associated with an increased risk of behavioural problems in children at 7 years of age. |
Keywords: | Antidepressive agents child development pregnancy prenatal exposure selective serotonin reuptake inhibitors |
Rights: | © 2015 Royal College of Obstetricians and Gynaecologists |
DOI: | 10.1111/1471-0528.13611 |
Published version: | http://dx.doi.org/10.1111/1471-0528.13611 |
Appears in Collections: | Aurora harvest 8 Paediatrics publications |
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hdl_106228.pdf | Accepted Version | 1.23 MB | Adobe PDF | View/Open |
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