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Type: Journal article
Title: Prenatal antidepressant exposure and child behavioural outcomes at 7 years of age: a study within the Danish National Birth Cohort
Author: Grzeskowiak, L.
Morrison, J.
Henriksen, T.
Bech, B.
Obel, C.
Olsen, J.
Pedersen, L.
Citation: BJOG: An International Journal of Obstetrics and Gynaecology, 2016; 123(12):1919-1928
Publisher: Blackwell Publishing
Issue Date: 2016
ISSN: 1470-0328
Statement of
LE Grzeskowiak, JL Morrison, TB Henrikse, BH Bech, C Obel, J Olsen, LH Pedersen
Abstract: Objective: To investigate the impact of prenatal antidepressant exposure on behavioural problems in children at 7 years of age. Design: Nationwide population-based study. Setting: Danish National Birth Cohort. Population: A cohort of 49 178 pregnant women recruited between 1996 and 2002. Methods: Data obtained from computer-assisted telephone interviews twice during pregnancy were used to identify children born to: (i) depressed women who took antidepressants during pregnancy (n = 210); (ii) depressed women who did not take any antidepressants during pregnancy (n = 231); and (iii) healthy women who were not depressed (n = 48 737). Childhood behavioural problems at 7 years of age were examined using the validated Danish parent-report version of the Strengths and Difficulties Questionnaire (SDQ). Main outcome measures: SDQ scores. Results: No associations were observed between prenatal antidepressant exposure and abnormal SDQ scores for overall problem behaviour (adjusted relative risk, aRR 1.00; 95% confidence interval, 95% CI 0.49–2.05), hyperactivity/inattention (aRR 0.99; 95% CI 0.56–1.75), or peer problems (aRR 1.04; 95% CI 0.57–1.91). Although prenatal antidepressant exposure appeared to be associated with abnormal SDQ scores on the subscales of emotional symptoms (aRR 1.68; 95% CI 1.18–2.38) and conduct problems (aRR 1.58; 95% CI 1.03–2.42), these associations were significantly attenuated following adjustment for antenatal mood status (aRR 1.20; 95% CI 0.85–1.70 and aRR 1.19; 95% CI 0.77 1.83, respectively). Untreated prenatal depression was associated with an increased risk of all behavioural outcomes evaluated, compared with unexposed children, with significant attenuation following adjustment for antenatal mood status. Conclusions: The results of this study suggest that independent of maternal illness, prenatal antidepressant exposure is not associated with an increased risk of behavioural problems in children at 7 years of age.
Keywords: Antidepressive agents; child development; pregnancy; prenatal exposure; selective serotonin reuptake inhibitors
Rights: © 2015 Royal College of Obstetricians and Gynaecologists
RMID: 0030036446
DOI: 10.1111/1471-0528.13611
Appears in Collections:Paediatrics publications

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