Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/106266
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Type: Journal article
Title: Novel and nonpharmacologic approaches to cardio-protection in hypertension
Author: Donazzan, L.
Mahfoud, F.
Linz, D.
Ewen, S.
Ukena, C.
Böhm, M.
Citation: Current Hypertension Reports, 2014; 16(5):430-1-430-9
Publisher: Springer
Issue Date: 2014
ISSN: 1522-6417
1534-3111
Statement of
Responsibility: 
Hypertension; resistant hypertension; renal sympathetic denervation; baroreceptor stimulation; heart failure; left ventricular hypertrophy; cardiac arrhythmias; vascular remodeling
Abstract: Hypertension has wide (30-45 %) prevalence in the general population and is related to important increases in overall cardiovascular morbidity and mortality. Despite lifestyle modifications and optimal medical therapy (three drugs, one being diuretic), about 5-20 % of hypertensives are affected by resistant hypertension. Chronic high blood pressure has adverse effects on the heart and other organs such as the kidneys and vasculature. Renal sympathetic denervation and baroreceptor stimulation are invasive approaches initially investigated to treat resistant hypertension. Their pleiotropic effects appear promising in cardiovascular remodeling, heart failure and arrhythmias and could potentially affect cardiovascular morbidity and mortality.
Keywords: Hypertension; resistant hypertension; renal sympathetic denervation; baroreceptor stimulation; heart failure; left ventricular hypertrophy; cardiac arrhythmias; vascular remodeling
Rights: © Springer Science+Business Media New York 2014
DOI: 10.1007/s11906-014-0430-3
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Pharmacology publications

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