Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/106615
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dc.contributor.authorChandrasegaram, M.en
dc.contributor.authorChen, J.en
dc.contributor.authorPrice, T.en
dc.contributor.authorZalcberg, J.en
dc.contributor.authorSjoquist, K.en
dc.contributor.authorMerrett, N.en
dc.date.issued2016en
dc.identifier.citationPancreas, 2016; 45(1):32-39en
dc.identifier.issn0885-3177en
dc.identifier.issn1536-4828en
dc.identifier.urihttp://hdl.handle.net/2440/106615-
dc.description.abstractObjectives: Periampullary cancers (PACs) include the following 4 traditional anatomic subtypes: pancreatic, ampullary, biliary, or duodenal cancers. This review was performed to highlight recent advances in the genomic and molecular understanding of each PAC subtype and the advances in chemotherapeutic and molecular trials in these cancer subtypes. Results: Recent advances have highlighted differences in the genomic and molecular features within each PAC subtype. Ampullary cancers can now be further defined accurately into their intestinal and pancreatobiliary subtypes using histomolecular profiling. K-ras mutation, which occurs in most pancreatic cancers, is found to occur less frequently in ampullary (42%-52%), biliary (22%-23%), and duodenal cancers (32%-35%), suggesting crucial differences in targetable mutations in these cancer subtypes. Ampullary cancers of intestinal subtype and duodenal cancers seem to share similarities with colorectal cancer, given that they respond to similar chemotherapeutic regimens. This has potential implications for clinical trials and treatment selection, where PACs are often considered together. Conclusions: Future trials should be designed in view of our increased understanding of the different anatomic and histomolecularly profiled subtypes of PAC cancers, which respects their individual molecular characteristics, phenotype, and response to treatment.en
dc.description.statementofresponsibilityManju D. Chandrasegaram, John W. Chen, Timothy J. Price, John Zalcberg, Katrin Sjoquist, and Neil D. Merretten
dc.language.isoenen
dc.publisherWolters Kluwer Health Inc.en
dc.rightsCopyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.en
dc.subjectPeriampullary cancer; pancreatic cancer; ampullary cancer; biliary cancer; duodenal cancer; K-ras mutationen
dc.titleAdvances in molecular pathology and treatment of periampullary cancersen
dc.typeJournal articleen
dc.identifier.rmid0030034991en
dc.identifier.doi10.1097/MPA.0000000000000385en
dc.identifier.pubid213541-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidChandrasegaram, M. [0000-0002-4826-5038]en
dc.identifier.orcidPrice, T. [0000-0002-3922-2693]en
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