Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/10675
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Type: Journal article
Title: Excision of laparoscopic port sites increases the likelihood of wound metastases in an experimental model
Author: Watson, D.
Ellis, T.
Leeder, P.
Neuhaus, S.
Dodd, T.
Jamieson, G.
Citation: Surgical Endoscopy: surgical and interventional techniques, 2003; 17(1):83-85
Publisher: Springer
Issue Date: 2003
ISSN: 0930-2794
1432-2218
Statement of
Responsibility: 
D.I. Watson, T. Ellis, P.C. Leeder, S.J. Neuhaus, T. Dodd and G.G. Jamieson
Abstract: Background: Case reports of patients developing tumor metastases at port sites following laparoscopic surgery have prompted the development of preventive strategies to address this potential problem, including local excision of the port sites. While it has been suggested that this strategy could be used clinically, its efficacy has not been established. Methods: Twenty four immune-competent Dark Agouti rats underwent laparoscopy and standardized intraperitoneal laceration of an implanted abdominal flank tumor, using an established laparoscopic cancer model. Rats were randomized to either control (n = 12) or wound excision (n = 12) groups. Both groups underwent laparoscopy using carbon dioxide (CO2) insufflation and two mini-laparoscopy ports. In the wound excision group, one of the port site wounds was excised following desufflation of the abdominal cavity. One week later, the port site wounds were excised for histological examination. Results: Wound involvement with tumor was significantly more common following wound excision than with untreated control wounds (nine of 12 vs two of 12, p = 0.002). In the wound excision group, tumor metastases arose preferentially in the excised port site wound. Conclusion: This study suggests that excision of laparoscopy port site wounds following laparoscopic surgery for cancer does not prevent the subsequent development of port site tumors. Furthermore, the excision of port sites may actually increase the risk of tumor metastases arising in port sites, suggesting that the clinical application of this strategy should be avoided pending further evaluation.
Keywords: Rodentia
Inlet zone
Australia
Laparoscopy
Mammalia
Digestive diseases
Malignant tumor
Oceania
Skin disease
Endoscopic surgery
Vertebrata
Abdomen
Metastasis
Experimental disease
Description: The original publication is available at www.springerlink.com
DOI: 10.1007/s00464-002-8838-2
Description (link): http://cat.inist.fr/?aModele=afficheN&cpsidt=14589996
Appears in Collections:Aurora harvest 7
Surgery publications

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