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|Title:||Hematogenous spread as a mechanism for the generation of abdominal wound metastases following laparoscopy|
|Citation:||Surgical Endoscopy: surgical and interventional techniques, 2002; 16(2):292-295|
|Abstract:||<h4>Background</h4>We designed this study to determine whether hematogenous spread has a role in the etiology of port site metastases following laparoscopic surgery.<h4>Methods</h4>The study design had two parts. In experiment 1, two groups (n = 30) of male Dark Agouti rats were studied. Under general anesthesia, the first group (20 rats) underwent 15 mins of laparoscopic insufflation, followed by an injection of a suspension of 105 Dark Agouti mammary adenocarcinoma (DAMA) cells into the internal jugular vein and a further 15-mins period of insufflation. The laparoscopic ports were then removed, and the wounds were closed and marked. In the second group (n = 10), the procedure was identical except that a 2.5-cm midline laparotomy was performed 15 mins after the commencement of anesthesia and insufflation was not used. The laparotomy was closed in two layers. In experiment 2, one group (n = 4) was studied. The study protocol was identical to the first laparoscopic group except that a larger number of 106 DAMA cells were injected. All rats in both experiments were killed 15 days later, and the injection site, laparoscopy wounds, and laparotomy wound were examined histologically by a blinded histopathologist.<h4>Results</h4>In experiment 1, one port site tumor was detected in the laparoscopic group and no wound metastases were found in the laparotomy group. Postoperative weight loss was significantly less in the laparoscopic group (p < 0.001). In experiment 2, no port site metastases were detected.<h4>Conclusion</h4>Although hematogenous spread is a possible mechanism in the development of port site metastases, judging from the low number of port site metastases in this study as compared to previous reports using this tumor model, this mechanism is unlikely to be a major contributor to the problem of wound metastasis following laparoscopy.|
Rats, Inbred Strains
Mammary Neoplasms, Experimental
Disease Models, Animal
|Appears in Collections:||Aurora harvest 2|
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