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Type: Journal article
Title: Biomimetic silica nanocapsules for tunable sustained release and cargo protection
Author: Yang, G.
Wibowo, D.
Yun, J.
Wang, L.
Middelberg, A.
Zhao, C.
Citation: Langmuir: the ACS journal of surfaces and colloids, 2017; 33(23):5777-5785
Publisher: American Chemical Society
Issue Date: 2017
ISSN: 0743-7463
Statement of
Guang-Ze Yang, David Wibowo, Jung-Ho Yun, Lianzhou Wang, Anton P.J. Middelberg, and Chun-Xia Zhao
Abstract: Silica nanocapsules have attracted tremendous interest for encapsulation, protection, and controlled release of various cargoes due to their unique hierarchical core−shell structure. However, it remains challenging to synthesize silica nanocapsules having high cargo-loading capacity and cargoprotection capability without compromising process simplicity and biocompatibility properties. Here, we synthesized oil-core silica-shell nanocapsules under environmentally friendly conditions by a novel emulsion and biomimetic dualtemplating approach using a dual-functional protein, in lieu of petrochemical surfactants, thus avoiding the necessities for the removal of toxic components. A light- and pH-sensitive compound can be facilely encapsulated in the silica nanocapsules with the encapsulation efficiency of nearly 100%. Release of the encapsulated active from the nanocapsules was not shown an indication of undesired burst release. Instead, the release can be tuned by controlling the silica-shell thicknesses (i.e., 40 and 77 nm from which the cargo released at 42.0 and 31.3% of the initial amount after 32 days, respectively). The release kinetics were fitted well to the Higuchi model, enabling the possibility of the prediction of release kinetics as a function of shell thickness, thus achieving design-for-purpose silica nanocapsules. Furthermore, the nanocapsules showed excellent alkaline- and sunlight-shielding protective efficacies, which resulted in significantly prolonged half-life of the sensitive cargo. Our biomimetic silica nanocapsules provide a nanocarrier platform for applications that demand process scalability, sustainability, and biocompatibility coupled with unique cargo-protection and controlled-release properties.
Keywords: Silicon Dioxide
Delayed-Action Preparations
Rights: © 2017 American Chemical Society
DOI: 10.1021/acs.langmuir.7b00590
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